CerviCo-Vaginal Dysbiosis as Risk Factor for Sexually Transmitted Diseases: Insights from Molecular Researches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 4522
Special Issue Editor
Interests: identification of host defence factors towards C. trachomatis genital infection; study of C. trachomatis role in the pathogenesis of male infertility; study of chlamydia-host cell interaction; identification of new anti-chlamydial drugs; study of the etiopathogenic role Chlamydia pneumoniae in the chronic inflammatory diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The genital microenvironment is an ecological niche characterized by a dynamic balance between numerous aerobic and anaerobic microorganisms that constitute the resident microbiota, widely considered as an important defense factor in the female genital tract against invading pathogens. In healthy women, the genital microbiota is typically dominated by several Lactobacillus species, conferring protection against infections through several mechanisms, such as competitive exclusion and the production of hydrogen peroxide and bacteriocins. By contrast, the depletion of lactobacilli and the overgrowth of a wide array of strict and facultative anaerobes—including Gardnerella vaginalis, Atopobium vaginae and Prevotella spp.—leads to a condition called dysbiosis that has been associated with an increased risk of sexually transmitted infections, such as Chlamydia trachomatis, Neisseria gonorrhoeae, HPV, HIV, etc.
This Special Issue aims to gather the most recent evidence on either genital dysbiosis as a risk factor for sexually transmitted infections or the protective activity of a lactobacillus-dominated microbiota. Studies on microbe-associated molecular patterns will also be considered. Overall, this will provide a more comprehensive picture of the multifaceted role of the cervico-vaginal microenvironment regarding infectious agents.
You may choose our Joint Special Issue in Reproductive Medicine.
Prof. Rosa Sessa
Guest Editor
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Keywords
- Sexually transmitted diseases
- Cervico-vaginal microbiota
- Dysbiosis
- Microbe-associated molecular patterns
- Next-generation sequencing
- Metabolomic
- Proteomic.
