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Special Issue "Chemokine Receptor and Ligands on Pain and Itch"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Sara Jane Ward
E-Mail Website
Guest Editor
Center for Substance Abuse Research, Lewis Katz School of Medicine, Philadelphia, PA 19104, USA
Interests: role of cannabinoids and the endocannabinoid system in pain and itch; modulation of neuroinflammation by cannabinoids and opioids for pain, itch, and reward
Dr. Saadet Inan
E-Mail Website
Guest Editor
Center for Substance Abuse Research, Lewis Katz School of Medicine, Philadelphia, PA 19104, USA
Interests: role of chemokine and cytokine release during development of acute and chronic pain and itch; heterologous desensitization between chemokines and opioids; therapeutic value of chemokine receptor antagonists alone and in combination with opioids for pain and itch; pruritic and antipruritic effects of kappa opioid receptor ligands

Special Issue Information

Dear Colleagues,

Studies on chemokine receptors and their ligands evidently showed that they play an important role in the development of chronic pain and itch. Latest reports clearly indicate that prevalence of patients suffer from chronic itch is as high as in chronic pain. Despite increased research on development of effective analgesic and antipruritic compounds without severe side effects, still there is no effective medication approved for both condition other than opioids. A Special Issue of the International Journal of Molecular Sciences on “Chemokine receptors and ligands on pain and itch: Potential therapeutic applications of chemokine receptor antagonists” aims to bring attention on chemokine receptors and their ligands as novel molecular targets for pain and itch, and to new compounds in clinical development for treating chronic pain and itch.

Research articles and reviews on basic, preclinical, and clinical studies with biomolecular results are all welcome.

Dr. Sara Jane Ward
Dr. Saadet Inan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chemokine receptor
  • chemokines
  • cytokines
  • chemokine receptor antagonist
  • acute pain
  • chronic pain
  • acute itch
  • chronic itch
  • scratching
  • allodynia
  • neuropathic pain
  • neuropathic itch
  • neuroinflammation

Published Papers

This special issue is now open for submission.
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