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Special Issue "Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 April 2021.

Special Issue Editors

Dr. Cecilia Prata
Guest Editor
Department of Pharmacy and Biotechnology, Alma Mater Studiorum - Università di Bologna, Bologna, Italy
Interests: Cell biochemistry and nutrition
Dr. Tullia Maraldi
Guest Editor
Department of Biomedical, Metabolic and Neural Sciences - University of Modena and Reggio Emilia, Modena, Italy
Interests: Stem cells and age-related disorders
Special Issues and Collections in MDPI journals
Prof. Cristina Angeloni
Guest Editor

Special Issue Information

Dear Colleagues,

The great increase of life expectancy is linked to the necessity of counteracting chronic-degenerative diseases, e.g., cancer, metabolic syndrome, type 2 diabetes, cardiovascular, and neurodegenerative diseases that affect a high percentage of the population. Since oxidative stress and inflammation are common features of these diseases and impact differently on function and structure of organs and tissues, the aim of this Special Issue is to collect original articles and reviews on this multifaceted topic that still remains largely unexplored, in order to provide support for the development of novel potential therapeutic approaches.

Suggested topics include but are not limited to:

- Cellular and molecular mechanisms to counteract oxidative stress and inflammation in aging and chronic diseases;

- Dietetic strategies for prevention of chronic diseases: oxidative stress as a target for interventions;

- Association of drugs with antioxidant or anti-inflammatory compounds for the therapy of chronic diseases.

Dr. Cecilia Prata
Dr. Tullia Maraldi
Prof. Dr. Cristina Angeloni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic-degenerative diseases
  • oxidative stress
  • inflammation
  • nutrition
  • nutraceuticals
  • stem cell therapy

Published Papers (1 paper)

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Open AccessArticle
The Interplay between HGF/c-met Axis and Nox4 in BRAF Mutated Melanoma
Int. J. Mol. Sci. 2021, 22(2), 761; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020761 - 13 Jan 2021
Background: Melanoma is the leading cause of death due to cutaneous malignancy and its incidence is on the rise. Several signaling pathways, including receptor tyrosine kinases, have a role in the development and progression of melanocytic lesions and malignant melanoma. Among those, the [...] Read more.
Background: Melanoma is the leading cause of death due to cutaneous malignancy and its incidence is on the rise. Several signaling pathways, including receptor tyrosine kinases, have a role in the development and progression of melanocytic lesions and malignant melanoma. Among those, the hepatocyte growth factor (HGF)/c-met axis is emerging as a critical player because it can play a role in drug resistance. Indeed, 50% of melanoma patients present BRAF mutations, however, all responders develop resistance to the inhibitors typically within one year of treatment. Interestingly, BRAF inhibitors induce reactive oxygen species (ROS) in melanoma cells, therefore, the aim of this study was to investigate a possible interplay between HGF/c-met and ROS sources, such as NADPH oxidases (Nox). Methods: The expression of c-met and Nox were quantified in 60 patients with primary cutaneous melanoma. In vitro experiments on melanoma primary cells and the cell line were performed to dissect the underpinned molecular mechanism. Results: The outcome of interest was the correlation between the high positivity for both Nox4 and c-met and metastasis occurring at least 1 year later than melanoma diagnosis in BRAF mutated patients, in contrast to nonmutated. In vitro experiments demonstrated that the axis HGF/c-met/Nox4/ROS triggers the epithelial-mesenchymal transition. Conclusions: The observed correlation suggests an interplay between c-met and Nox4 in promoting the onset of metastasis. This study suggests that Nox4 inhibitors could be associated to the current therapy used to treat melanoma patients with BRAF mutations. Full article
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