Special Issue "The Risks of Ignoring the Invisible Damages of Concussion: From Molecules to Pathology"
Deadline for manuscript submissions: closed (31 July 2020).
Interests: mitochondrial dysfunction; energy metabolism; oxidative/nitrosative stress; antioxidants; neurodegenerations; traumatic brain injury; concussion and sports-related concussion; male and female infertility; HPLC analysis of metabolites
Special Issues and Collections in MDPI journals
Interests: TBI; animal models of TBI; microRNA
Concussion is a peculiar type of mild traumatic brain injury, frequently encountered in both contact (American football, boxing, martial arts, soccer, ice hockey) and noncontact (horse riding, alpine sky, car and moto races) sports. It occurs any time an external force, unnecessarily acting directly to the head, provokes rapid acceleration–deceleration of the brain. The consequences are evident at three levels: (i) clinical, with early and late symptoms spontaneously resolving (nearly in 100% of cases after the first concussion) in a relatively short time; (ii) neuropsychological, with cognitive deficits lasting slightly longer than neurological symptoms; and (iii) molecular, with an incredibly vast number of biochemical alterations of metabolic pathways and cycles, affecting cellular and subcellular functions, and lasting much longer than clinical symptoms and cognitive deficits. That is, concussion provokes silent and (almost) invisible changes of brain homeostasis, to date difficult to detect and monitor, causing a period of “vulnerability”, whose duration is scarcely predictable and during which the brain is exposed to catastrophic damages if a second concussion (second impact syndrome, SIS) should occur. Since concussive patients are negative on conventional neuroimaging techniques (CT scan, MRI) and symptoms rapidly clear off, concussion’s exact occurrence is largely underestimated, and sequelae of incomplete healing are dangerously under-concerned. Indeed, recurrent concussions may develop in progressive neurodegeneration, evolving into chronic traumatic encephalopathy (CTE).
The aim of this Special Issue is to receive original contributions or review articles on different aspects of concussion. Studies on concussion may be carried out either in animals or in humans and should be focused on highlighting new mechanisms negatively affecting cerebral cell functions, evidencing potential drug targets, determining new biomarkers which are useful to define healing and, in the case of athletes, their safe return to play, and reporting effective rehabilitation treatments. Ultimately, insights to better understand the molecular mechanisms triggering SIS or developing CTE would be highly esteemed.
Prof. Dr. Giuseppe Lazzarino
Dr. Valentina Di Pietro
Dr. Stefano Signoretti
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- sports-related concussion
- mitochondrial dysfunction
- oxidative/nitrosative stress
- brain energy metabolism
- biomarkers of concussion
- advanced neuroimaging techniques
- post-concussive rehabilitation