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Special Issue "Copper in Biology: Maturation of Copper Proteins and Copper Homeostasis 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editor

Dr. Francesca Cantini
Guest Editor
Magnetic Resonance Center (CERM)–University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy, and Department of Chemistry–University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
Interests: structural biology; solution NMR; protein structure determination by NMR; protein-small molecules interaction; protein-protein interaction; metalloproteins; metal homeostasis
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Special Issue Information

Dear Colleagues,

Copper is an essential transition metal ion found in many key human enzymes. Its ability to assume distinct redox states by cycling between oxidized copper(II) and reduced copper(I) makes copper an appropriate cofactor in proteins, showing a wide range of catalytic functions, such as reactive oxygen species detoxification, electron transfer and mitochondrial functions. Copper redox properties can also lead to cellular oxidative damage when it is found in excess concentrations. Copper can participate in reactions that lead to the production of highly-reactive oxidative species, which cause DNA damage and oxidation of proteins and lipids. Moreover, the ability of copper to bind at sites of other metal ions can have devastating effects for various cellular functions. In order to prevent the binding of the “wrong” copper ion, cells have developed very efficient homeostatic and trafficking mechanisms. Thus, copper distribution, exploitation and excretion is tightly regulated in cells. Molecular recognition by protein–protein interactions efficiently guarantees the correct delivery of copper to Cu-dependent enzymes.

This Special Issue, "Copper in Biology: Maturation of Copper Proteins and Copper Homeostasis", will be comprised of original research papers and reviews covering various aspects of the field. An overview on copper proteins will be considered, and original papers aim to unravel the precise molecular nature of copper within different cellular compartments are welcome. Contributions that show recent advances in maturation of copper proteins and copper homeostasis processes will be also considered.

Dr. Francesca Cantini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessReview
Advances in Understanding of the Copper Homeostasis in Pseudomonas aeruginosa
Int. J. Mol. Sci. 2021, 22(4), 2050; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042050 - 19 Feb 2021
Thirty-five thousand people die as a result of more than 2.8 million antibiotic-resistant infections in the United States of America per year. Pseudomonas aeruginosa (P. aeruginosa) is classified a serious threat, the second-highest threat category of the U.S. Department of Health [...] Read more.
Thirty-five thousand people die as a result of more than 2.8 million antibiotic-resistant infections in the United States of America per year. Pseudomonas aeruginosa (P. aeruginosa) is classified a serious threat, the second-highest threat category of the U.S. Department of Health and Human Services. Among others, the World Health Organization (WHO) encourages the discovery and development of novel antibiotic classes with new targets and mechanisms of action without cross-resistance to existing classes. To find potential new target sites in pathogenic bacteria, such as P. aeruginosa, it is inevitable to fully understand the molecular mechanism of homeostasis, metabolism, regulation, growth, and resistances thereof. P. aeruginosa maintains a sophisticated copper defense cascade comprising three stages, resembling those of public safety organizations. These stages include copper scavenging, first responder, and second responder. Similar mechanisms are found in numerous pathogens. Here we compare the copper-dependent transcription regulators cueR and copRS of Escherichia coli (E. coli) and P. aeruginosa. Further, phylogenetic analysis and structural modelling of mexPQ-opmE reveal that this efflux pump is unlikely to be involved in the copper export of P. aeruginosa. Altogether, we present current understandings of the copper homeostasis in P. aeruginosa and potential new target sites for antimicrobial agents or a combinatorial drug regimen in the fight against multidrug resistant pathogens. Full article
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