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Special Issue "Dendritic Cell and Cancer Therapy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editor

Dr. Domenico Galati
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Guest Editor
Haematology-Oncology and Stem Cell Transplantation Unit, Department of Haematology and Developmental Therapeutics, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italia
Interests: dendritic cells; immunotherapy; gamma-delta T cells; cancer biomarkers; tumor immunology; gamma-delta T cells; cytometry

Special Issue Information

Dear Colleagues,

The strategies for cancer immunotherapy have obtained mixed results mainly due to immune suppression and several immune escape mechanisms induced by tumor cells. In this regard, Dendritic Cells have become a hopeful instrument for cancer vaccines that aims to re-educate the immune system, leading to a potent anti-cancer response that is able to overcome the immunosuppressive tumor microenvironment. However, cancer cells can deregulate Dendritic Cell function by a combination of different mechanisms, including antigen down-regulation and secretion of molecules that together adjust the immune-stimulating or the immune-suppressive functional plasticity of Dendritic Cells. 

Therefore, new insights will be helpful to define molecules and pathways that can modulate the performance of Dendritic Cell subsets. In particular, a better comprehension of the complex interactions occurring in the tumor microenvironment will undoubtedly improve the design of really efficient and durable immunotherapeutic approaches for tumor disease control.

Dr. Domenico Galati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dendritic cells
  • dendritic cell subsets
  • cancer immunotherapy
  • immune suppression
  • cancer vaccines
  • anti-cancer response
  • tumor microenvironment

Published Papers (2 papers)

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Research

Article
Immunostimulatory Potential of Extracellular Vesicles Isolated from an Edible Plant, Petasites japonicus, via the Induction of Murine Dendritic Cell Maturation
Int. J. Mol. Sci. 2021, 22(19), 10634; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910634 - 30 Sep 2021
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Abstract
Extracellular vesicles (EVs) have recently been isolated from different plants. Plant-derived EVs have been proposed as potent therapeutics and drug-delivery nanoplatforms for delivering biomolecules, including proteins, RNAs, DNAs, and lipids. Herein, Petasites japonicus-derived EVs (PJ-EVs) were isolated through a series of centrifugation [...] Read more.
Extracellular vesicles (EVs) have recently been isolated from different plants. Plant-derived EVs have been proposed as potent therapeutics and drug-delivery nanoplatforms for delivering biomolecules, including proteins, RNAs, DNAs, and lipids. Herein, Petasites japonicus-derived EVs (PJ-EVs) were isolated through a series of centrifugation steps and characterized using dynamic light scattering and transmission electron microscopy. Immunomodulatory effects of PJ-EVs were assessed using dendritic cells (DCs). PJ-EVs exhibited a spherical morphology with an average size of 122.6 nm. They induced the maturation of DCs via an increase in the expression of surface molecules (CD80, CD86, MHC-I, and MHC-II), production of Th1-polarizing cytokines (TNF-α and IL-12p70), and antigen-presenting ability; however, they reduced the antigen-uptake ability. Furthermore, maturation of DCs induced by PJ-EVs was dependent on the activation and phosphorylation of MAPK and NF-κB signal pathways. Notably, PJ-EV-treated DCs strongly induced the proliferation and differentiation of naïve T cells toward Th1-type T cells and cytotoxic CD8+ T cells along with robust secretion of IFN-γ and IL-2. In conclusion, our study indicates that PJ-EVs can be potent immunostimulatory candidates with an ability of strongly inducing the maturation of DCs. Full article
(This article belongs to the Special Issue Dendritic Cell and Cancer Therapy)
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Article
Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer
Int. J. Mol. Sci. 2021, 22(17), 9125; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179125 - 24 Aug 2021
Viewed by 370
Abstract
Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on the induction of anti-cancer immunity in [...] Read more.
Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on the induction of anti-cancer immunity in the lung was examined by intranasal administration. In C57BL/6 and BALB/c mice, intranasal administration of ECF promoted the activation of dendritic cells (DCs), natural killer (NK) cells, and T cells in the mediastinal lymph node (mLN). The ECF-induced NK and T cell activation was mediated by DCs. In addition, intranasal injection with ECF enhanced the anti-PD-L1 antibody-mediated anti-cancer activities against B16 melanoma and CT-26 carcinoma tumor growth in the lungs, which were required cytotoxic T lymphocytes and NK cells. Thus, these data demonstrated that ECF functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer. Full article
(This article belongs to the Special Issue Dendritic Cell and Cancer Therapy)
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