ijms-logo

Journal Browser

Journal Browser

Impact of Diet on Cancer Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 2193

Special Issue Editor

Department of Nutrition, The University of Tennessee-Knoxville, Knoxville, TN 37996-1920, USA
Interests: metabolic diseases; obesity; type 2 diabetes; protein tyrosine phosphatases; protein kinases; hydrolases

Special Issue Information

Dear Colleagues,

Pharmacological approaches to combat cancer have been met with limited success despite intensive investments in their development. Over the past decade, the importance of dietary factors and caloric intake in modulating cancer risk has become increasingly apparent. Investigations targeting the contribution of caloric intake regarding cancer progression and development have revealed significant findings. Caloric restriction has demonstrated potential against various cancers through modulation of key signaling pathways important for various aspects of carcinogenesis including, inflammation, cell cycle, angiogenesis, autophagy, and apoptotic signaling pathways. Additionally, numerous natural dietary compounds including several calorie restriction mimetics have been investigated for their potential as either therapeutic or preventive agents against several types of cancer. However, further efforts towards a comprehensive understanding of the role of dietary factors in cancer biology, the metabolic and physiological consequences, as well as, their associated clinical outcomes are needed. Therefore, this issue will focus on the overall dietary effects on carcinogenesis and how alternative approaches may be potentiated as adjunct, first line and preventive care options.

Prof. Dr. Ahmed Bettaieb
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacological approaches
  • dietary factors
  • caloric intake
  • metabolism
  • cancer
  • calorie restriction
  • carcinogenesis
  • metabolic and physiological consequences

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

23 pages, 4782 KiB  
Article
A Fiber-Rich Diet and Radiation-Induced Injury in the Murine Intestinal Mucosa
by Dilip Kumar Malipatlolla, Sravani Devarakonda, Piyush Patel, Fei Sjöberg, Ana Rascón, Rita Grandér, Viktor Skokic, Marie Kalm, Jolie Danial, Eva Mehdin, Malin Warholm, Henrietta Norling, Andrea Stringer, Malin E. V. Johansson, Margareta Nyman, Gunnar Steineck and Cecilia Bull
Int. J. Mol. Sci. 2022, 23(1), 439; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23010439 - 31 Dec 2021
Cited by 3 | Viewed by 1819
Abstract
Dietary fiber is considered a strong intestinal protector, but we do not know whether dietary fiber protects against the long-lasting mucosal damage caused by ionizing radiation. To evaluate whether a fiber-rich diet can ameliorate the long-lasting pathophysiological hallmarks of the irradiated mucosa, C57BL/6J [...] Read more.
Dietary fiber is considered a strong intestinal protector, but we do not know whether dietary fiber protects against the long-lasting mucosal damage caused by ionizing radiation. To evaluate whether a fiber-rich diet can ameliorate the long-lasting pathophysiological hallmarks of the irradiated mucosa, C57BL/6J mice on a fiber-rich bioprocessed oat bran diet or a fiber-free diet received 32 Gray in four fractions to the distal colorectum using a linear accelerator and continued on the diets for one, six or 18 weeks. We quantified degenerating crypts, crypt fission, cell proliferation, crypt survival, macrophage density and bacterial infiltration. Crypt loss through crypt degeneration only occurred in the irradiated mice. Initially, it was most frequent in the fiber-deprived group but declined to levels similar to the fiber-consuming group by 18 weeks. The fiber-consuming group had a fast response to irradiation, with crypt fission for growth or healing peaking already at one week post-irradiation, while crypt fission in the fiber-deprived group peaked at six weeks. A fiber-rich diet allowed for a more intense crypt cell proliferation, but the recovery of crypts was eventually lost by 18 weeks. Bacterial infiltration was a late phenomenon, evident in the fiber-deprived animals and intensified manyfold after irradiation. Bacterial infiltration also coincided with a specific pro-inflammatory serum cytokine profile. In contrast, mice on a fiber-rich diet were completely protected from irradiation-induced bacterial infiltration and exhibited a similar serum cytokine profile as sham-irradiated mice on a fiber-rich diet. Our findings provide ample evidence that dietary fiber consumption modifies the onset, timing and intensity of radiation-induced pathophysiological processes in the intestinal mucosa. However, we need more knowledge, not least from clinical studies, before this finding can be introduced to a new and refined clinical practice. Full article
(This article belongs to the Special Issue Impact of Diet on Cancer Therapy)
Show Figures

Figure 1

Back to TopTop