Special Issue "Molecular Biomarkers of Selected Diseases of Civilization 2.0"
Deadline for manuscript submissions: 30 September 2021.
Interests: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins
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Diseases of civilization, also known as “lifestyle diseases” or “social diseases”, are spreading globally in an epidemic way. These non-infectious diseases, which are associated with the development of civilization, lead to disability and premature death. According to the World Health Organization, civilization diseases include Alzheimer’s disease and other neurodegenerative diseases, as well as cancer. Neurodegenerative diseases of the central nervous system, such as Alzheimer’s and Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, represent a major socioeconomic problem. There are different theories surrounding the pathogenesis of these diseases; however, their precise etiology remains unclear. Moreover, the availability of biomarkers with appropriate sensitivity and specificity that can predict treatment success is very limited. Another group of civilization diseases is malignant neoplasms, complex diseases with dysregulation of the cellular signaling that controls proliferation and apoptosis. These may be caused by various genetic, genomic, and epigenetic alterations at the cellular or tissue levels. There has been remarkable progress in the diagnosis and imaging of cancer patients. Furthermore, a worldwide decline in the incidence of certain malignancies has been observed. The survival of the majority of patients with solid tumors has also increased due to advances in surgery and therapy. However, some neoplasms, such as gastric, colorectal, pancreatic, and lung cancer or malignant tumors of the central nervous system, remain characterized by uncontrolled growth and high mortality, mostly due to delays in diagnosis. Therefore, there is still a need to find biomarkers that can help in the early diagnosis of cancer patients. The aim of this Special Issue is to provide new findings regarding molecular pathways and biomarkers that could improve the diagnosis and/or prognostic classification of neurodegeneration and cancer and to explore their potential clinical application in the detection and classification of these disorders.
This Special Issue will bring together original research and review articles on the molecular diagnostics of neurodegenerative diseases and cancer.
The topics of this Special Issue will include (but are not limited to):
- The influence of lifestyle and dietary factors in the development of neurodegeneration;
- Biological mechanisms related to neurodegeneration;
- Neurodegenerative diseases as proteinopathies;
- Neurodegeneration and inflammation;
- New potential biomarkers of Alzheimer’s disease and other neurodegenerative diseases: Alzheimer’s disease, mild cognitive impairment, multiple sclerosis, Parkinson’s disease, Lewy body dementia, frontotemporal dementia, amyotrophic lateral sclerosis, Huntington disease, and prion diseases;
- Biomarkers of neurodegeneration: prognostic value in conversion from mild cognitive impairment to fully symptomatic dementia;
- The role of vitamin deficiency and supplementation in cancer;
- Cytokines, chemokines, and matrix metalloproteinases as prognostic factors in carcinogenesis;
- Chemokines and their receptors as novel tumor markers in malignant tumors of the gastrointestinal tract; lung, breast, head, and neck cancer; and other solid tumors;
- Mediators of inflammation in various types of cancer and their relation to histological types of tumors.
Prof. Dr. Barbara Mroczko
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- neurodegenerative diseases
- cancer progression
- tumor markers
- prognostic biomarkers