Dear Colleagues,

We are pleased to announce the release of a Special Issue of the International Journal of Molecular Sciences on the topic of DNA DSB repair in the context of chromatin and mitochondrial dysfunctions in cells after exposure to ionizing radiation, and pathways of their modulation. We invite authors to submit your original scientific articles as well as thematic reviews.

As the results of many studies show, the induction of DNA double-strand breaks (DSB) and mitochondrial dysfunction, with increased oxidative stress, can be considered two critical events leading to cell death or the development of long-term consequences due to ionizing radiation (IR). Although there are significant achievements in this direction, additional knowledge is still required, using experimental models in vitro and in vivo. Further expansion of knowledge on these issues is of interest both for finding a means to reduce radiation damage and for improving the effectiveness of radiation therapy for cancer. Nuclear–mitochondrial signaling communications play an important role in cell survival and death. However, research in this aspect also requires further development after radiation exposure. Structural and functional disorders in mitochondria induced by IR lead to the development of a whole complex of effects at the level of cells and the whole organism. The mechanisms of repair of complex cluster DNA damage in mammalian cells induced by heavy densely ionizing particles have not yet been sufficiently elucidated. It is important to develop research to elucidate the repair of cluster DSB of DNA in the context of chromatin. The search for ways to modulate DSB of DNA repair and mitochondrial dysfunction, as well as studies on mitochondria-targeted radiomitigators, also remain very relevant.

Prof. Azhub Gaziev
Prof. Dr. Krasavin Evgeniy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• radiation damage and DNA repair
• cluster DSB of DNA
• pathways to preserve mitochondrial DNA (mtDNA)
• mitochondrial dysfunction
• mtDNA mutagenesis
• mitochondrial ROS
• degradation mtDNA
• extracellular circulating DNA
• mitophagy and mitogenesis
• radioprotectors and radiomitigators