Special Issue "DNA Polymerases and Beyond: Molecular Machines Responding to Replication Stress"
Deadline for manuscript submissions: 31 October 2021.
Interests: genome replication and repair in normal and tumor cells and human viruses; molecular virology; antiviral and anticancer drug development; molecular mechanisms of drug resistance
Interests: enzymology of DNA replication and repair; tyrosine kinases and proliferative signalling; antiviral and anticancer drug development
The control of the quality and integrity of genetic information as well as its correct duplication are central events for the maintenance of the cell homeostasis. Defects in these processes are at the basis of many pathological conditions, such as cancer, aging, and viral infections. DNA polymerases are at the core of DNA replication and repair pathways, which, however, involve the coordinated action of dozens of other proteins and enzymes. This Special Issue of the International Journal of Molecular Sciences, "DNA Polymerases and Beyond: Molecular Machines Responding to Replication Stress", will focus on the latest advances in understanding the complex network of interactions enabling cells to ensure accurate genome duplication and repair. Authors are invited to submit manuscripts addressing how different molecular steps such as DNA damage recognition and repair, DNA replication fork stalling and restart, and DNA stress signaling and tolerance are interconnected through the action of specialized enzymes and signaling molecules, including non-coding RNAs and metabolic intermediates. We aim at providing the scientific community with a fresh, broad view of the crucial aspects of cell metabolism, to stimulate new avenues of research and the asking of new questions.
Prof. Dr. Giovanni Maga
Dr. Emmanuele Crespan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA replication
- DNA repair
- Genomic instability
- DNA repair enzymes
- DNA damage signaling
- Non-coding RNAs
- Cell metabolism