Special Issue "Development of Dopaminergic Neurons"
Deadline for manuscript submissions: 30 September 2021.
Dopaminergic neurons located in the mammalian ventral midbrain have attracted the attention of many biomedical researchers due to their effect in severe human neuropsychiatric and neurodegenerative disorders. There are four major signalling pathways which play critical roles during the development of the midbrain dopaminergic (mDA) neurons. In spite of the intense research conducted in recent years, we have achieved little understanding related to the crosstalk and the interaction between those four major signalling pathways and how they promote the development of mDA neurons in the mammalian embryo. This has been a very exciting research field and a number of questions remain answering:
(1) Which cellular and molecular mechanisms constitute the basis for the programming of the development of VTA DA neurons versus SNc DA neurons in vivo?
2) What could be the explanation for the vulnerability of some types of mDA neurons in some neurodegenerative disorders?
(3) What will be the efficacy and safety outcomes of the clinical trials using human stem cell-derived mDA neurons?
Contributions to this Special Issue will provide new insights into the mechanisms of action of the development of DA neurons and for the modelling and drug screening of the disorders mentioned above in the basic and clinical research.
Dr. Yasemin M. Akay
Manuscript Submission Information
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- signalling pathways
- human stem cell