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Special Issue "Molecular Toxicology of Drug Induced Liver Injury"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Rolf Teschke
E-Mail Website
Guest Editor
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University, Frankfurt, Germany
Interests: alcoholic liver disease; alcoholic liver injury; alcohol metabolism; microsomal ethanol-oxidizing system; drug induced liver injury; herb induced liver injury; herbal traditional Chinese medicine (TCM); dietary supplements; causality assessment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Published reports suggest that some hundreds of drugs may be toxic, causing drug-induced liver injury (DILI), although evidence of a robust causal attribution for all incriminated drugs is not always provided. According to prevailing mainstream concepts, liver injury by drugs is due to overdosed drugs, causing intrinsic injury, or to drugs used in recommended doses, causing idiosyncratic liver injury. Whereas the molecular toxicology of the intrinsic liver injury is largely known from experimental and clinical studies, this does not apply to the idiosyncratic liver injury due to the lack of data reproducibility in animal models. As a result, studies on molecular toxicology are mostly limited to clinical research focusing on patients with idiosyncratic liver injury assessed for causality using preferentially the Roussel Uclaf Causality Assessment Method (RUCAM), a diagnostic algorithm in worldwide use and applied in most national and regional DILI registries like in Spain, Iceland, the Latin American region, and many Asian countries including Japan, China, and Korea. Possible keywords for submissions are diagnostic biomarkers, genetics, immune mechanisms, reactive oxygen species (ROS), cytochrome P450 (CYP), blood exosomes, and risk factors under discussion such as drug lipophilicity, daily dose, and metabolic rate. The aim of this Special Issue is to provide a broad updated overview on these molecule-related liver injury features with their challenges and highlights and to foster more molecular research in DILI. Experts in the field are encouraged to contribute their new results and views to this emerging and fascinating topic of molecular aspects. Since some topics are still controversial, we expect expert submissions and appreciate lively discussions, in addition to well-settled issues that are relevant to the clinical setting of molecular DILI and require balanced statements.

Prof. Dr. Rolf Teschke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • liver injury
  • drug-induced liver injury (DILI)
  • hepatotoxicity
  • molecular toxicology
  • drug toxicology

Published Papers

This special issue is now open for submission.
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