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Special Issue "Dry Eye Disease–Focus on Drug Discovery and Development"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Simon Kaja
E-Mail Website
Guest Editor
Department of Ophthalmology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
Interests: ophthalmic drugs; dry eye disease; ocular surface disease; drug delivery; ocular pharmacology; ocular toxicology; glaucoma; antioxidants; angiogenesis

Special Issue Information

Dear Colleagues,

Dry eye disease is one of the most prevalent diseases and one of the most common ophthalmic complaints encountered in clinical practice. Dry eye disease is of multifactorial origin and describes a clinically diverse group of ocular surface diseases associated with age-related changes to the various tissues of the ocular surface, immunological conditions such as Sjogren’s syndrome and ocular graft-vs-host disease (oGvHD), as well as surgical interventions. Current approved treatment modalities are subtype-specific and primarily target inflammatory pathways; there remains an urgent unmet clinical need for more efficacious and better-tolerated therapies.

In this Special Issue of IJMS, we are seeking articles that can accelerate drug discovery and development for dry eye disease by providing novel insights into the underlying mechanisms of dry eye disease, describing the standardization and validation of new animal models for dry eye disease, and investigating new therapeutic and drug delivery modalities. We welcome both preclinical and clinical studies. Manuscripts utilizing non-rodent models for dry eye disease subtypes are particularly encouraged.

Dr. Simon Kaja
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • dry eye
  • pathophysiology
  • treatment
  • animal model
  • cornea
  • Meibomian gland
  • lacrimal gland
  • inflammation
  • oxidative stress

Published Papers

This special issue is now open for submission.
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