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Special Issue "Mechanisms of Endocrine and Molecular Bone Regulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Prof. Dr. Jean Pierre Salles
Guest Editor
CHU de Toulouse, INSERM UMR 1043 CNCRS 5828 (CPTP), University of Toulouse, Toulouse, France
Interests: mechanisms of endocrine and bone regulation; rare endocrine and bone diseases; molecular signaling of hormones; regulation of calcium metabolism; Prader–Willi syndrome pathophysiology
Prof. Dr. Agnes Linglart
E-Mail Website
Co-Guest Editor
1. AP-HP, endocrinology and diabetes for children, Paris-Saclay Hospital, Le Kremlin Bicêtre, France
2. Université Paris-Saclay, INSERM, Physiologie et Physiopathologie Endocriniennes, Le Kremlin-Bicêtre, France
Interests: pediatric endocrinology; bone; calcium and phosphate metabolism; growth

Special Issue Information

Dear Colleagues,

Bone regulation offers striking new opportunities for its better understanding. Integration between molecular and endocrine mechanisms reveals unexpected relationships. Discovery of new agents involved in bone development has opened wide perspectives for the physiology and treatment of bone diseases and osteoporosis. Systemic regulation of bone mass by hormones such as growth hormone and IGF1, sex steroids, but also neuroendocrine hormones like leptin, ghrelin, oxytocin or other putative regulators during development and beyond is prominent. New actors such as FGF23 have appeared. The control of bone mass under recruitment and differentiation of osteoblasts precursors, as well as the role of osteocyte under mechanic stimulation, remain a still largely unexplored area. Local paracrine regulators, namely linked to the sclerostin pathway, seem also prominent. The goal is to provide an integrative vision of the main systemic and local regulators of bone mass, with special regard to new therapeutic options. 

Prof. Dr. Jean Pierre Salles
Prof. Agnes Linglart 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Bone mass
  • IGF1
  • Growth hormone
  • FGF23
  • Oxytocin
  • Leptin
  • Osteoblast
  • Osteocyte
  • GNAS
  • ALPL
  • PPi
  • Sclerostin

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: 11BHSD1 mediates the bone protective effects of glucocorticoids when administered in chronic inflammation
Authors: Chloe G Fenton, Simon W Jones, Andrew Filer Mark Cooper, Gareth G Lavery, Karim Raza, Ramon Langen, Rowan Hardy
Affiliation: University of Birmingham

Title: Sclerostin: from molecule to clinical biomarker
Authors: Ahmed Omran; Diana Atanasova; Filip Landgren; Per Magnusson
Affiliation: Department of Clinical Chemistry, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
Abstract: The regulation of bone remodeling is strongly dependent on Wnt signaling, where activation of the Wnt pathway leads to increased bone mass and inactivation leads to bone loss. Sclerostin, a 22-kDa glycoprotein encoded by the SOST gene, is mainly produced by osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling. Besides inhibiting bone formation and osteoblastogenesis, it has also been demonstrated that sclerostin stimulates osteoclastogenesis and bone resorption. The osteocyte network is a vast and highly complex communication network and orchestrate the function of osteoblasts and osteoclasts in response to both mechanical and hormonal cues. The expression of sclerostin is limited to mature osteocytes. Downregulation of the SOST gene and local Wnt signaling are required for the osteogenic response to mechanical loading. Sclerostin is also present in the circulation and evidence suggests that sclerostin might also exert an endocrine function. Different immunoassays for the assessment of serum sclerostin are commercially available; however, differences due to immunoassay variability have been reported. Second generation assays for sclerostin, designated as bioactive sclerostin, have recently been developed, which might overcome some of the reported methodological obstacles. Current knowledge of sclerostin, with a focus on osteogenesis and methodological aspects of modern immunoassays, is summarized in this review.

Authors: Nele A. Stumper; Hilke Wientgen; Leith Al-Hashimi; Hans-Werner Müller; Sarah Ohrndorf; Heide Siggelkow; Paula Hoff
Affiliation: Endokrinologikum Göttingen and Georg-August-Universität Göttingen, 37075 Göttingen, Germany
Abstract: (1) Background: The clinical relevance of aromatase to a functioning male metabolism has become evident since 1991, when cases of patients with estrogen deficiency caused by aromatase mutation were first described. Only few cases are known so far, which will now be presented in a case report and review of the literature. (2) Methods: All available publications since the first description in 1991 dealing with loss-of-function aromatase mutation in men were summarized and our care report added. (3) Results: The mutations that cause the aromatase protein to lose function lead to a rather heterogeneous clinical picture. It is, however, clear that estrogens play a central role in male patients, especially in bone metabolism. Most frequently, tall stature, unclosed epiphyseal joints, and osteoporosis are detected in affected individuals as a consequence of the change in hormonal status. (4) Conclusions: Despite aromatase deficiency being a rare disease, the study of the effects of estrogen on male bone development provides important insights for endocrine bone regulation. It has been demonstrated that androgens alone are not sufficient for adequate skeletal development in males. This work highlights the important role of estrogens in individual health and disease in men.

Title: Bone metabolic features in Multiple Endocrine Neoplasia Type 1
Authors: Maria Luisa Brandi; Francesca Marini
Affiliation: University of Florence, Medical School, Florence

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