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Special Issue "Novel Insights on the Molecular Aspects of Endocrine Disorders in Childhood"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 August 2021).

Special Issue Editor

Dr. Tommaso Aversa
E-Mail Website
Guest Editor
Department of Human Pathology of Adulthood and Childhood "Gaetano Barresi", University of Messina, Messina, Italy
Interests: thyroid diseases in childhood; growth; puberty; GH deficiency; childhood obesity; Turner syndrome; adrenal disorders in childhood

Special Issue Information

Dear Colleagues,

Diagnostic pathways and therapeutic targets of endocrine diseases in children and adolescents are constantly evolving, favored by advances in molecular sciences that offer new opportunities to clinicians. Hence the need for the pediatrician and above all for the pediatric endocrinologist to be continually brought up to date. Moreover, there is always a certain peculiarity and specificity of endocrine pathologies for children and adolescents.

The aim of this Special Issue is to provide an update on the molecular bases of endocrine disorders commonly treated by pediatric endocrinologists. In fact, an accurate molecular diagnosis allows a more customized genetic counseling and leads to a precise and personalized medicine. Therefore, increasing the knowledge of the etiological and pathophysiological mechanisms is of paramount importance for researchers and clinicians.

This Special Issue welcomes original research and review articles in the field of pediatric endocrinology, with a focus on (but not limited to) its molecular aspects.

Dr. Tommaso Aversa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Thyroid diseases in childhood
  • Growth disorders
  • GH deficiency
  • Turner syndrome
  • Puberty
  • Childhood obesity
  • Adrenal diseases in childhood

Published Papers (2 papers)

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Review

Review
Coaggregation of Asthma and Type 1 Diabetes in Children: A Narrative Review
Int. J. Mol. Sci. 2021, 22(11), 5757; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115757 - 28 May 2021
Cited by 1 | Viewed by 840
Abstract
Asthma and type 1 diabetes mellitus (T1DM) are two of the most frequent chronic diseases in children, representing a model of the atopic and autoimmune diseases respectively. These two groups of disorders are mediated by different immunological pathways, T helper (Th)1 for diabetes [...] Read more.
Asthma and type 1 diabetes mellitus (T1DM) are two of the most frequent chronic diseases in children, representing a model of the atopic and autoimmune diseases respectively. These two groups of disorders are mediated by different immunological pathways, T helper (Th)1 for diabetes and Th2 for asthma. For many years, these two groups were thought to be mutually exclusive according to the Th1/Th2 paradigm. In children, the incidence of both diseases is steadily increasing worldwide. In this narrative review, we report the evidence of the potential link between asthma and T1DM in childhood. We discuss which molecular mechanisms could be involved in the link between asthma and T1DM, such as genetic predisposition, cytokine patterns, and environmental influences. Cytokine profile of children with asthma and T1DM shows an activation of both Th1 and Th2 pathways, suggesting a complex genetic-epigenetic interaction. In conclusion, in children, the potential link between asthma and T1DM needs further investigation to improve the diagnostic and therapeutic approach to these patients. The aim of this review is to invite the pediatricians to consider the potential copresence of these two disorders in clinical practice. Full article
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Review
Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis
Int. J. Mol. Sci. 2021, 22(4), 2058; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042058 - 19 Feb 2021
Viewed by 1514
Abstract
The review summarizes the results of experimental and clinical studies aimed at elucidating the causes and pathophysiological mechanisms of the development of endocrine pathology in children. The modern data on the role of epigenetic influences in the early ontogenesis of unfavorable factors that [...] Read more.
The review summarizes the results of experimental and clinical studies aimed at elucidating the causes and pathophysiological mechanisms of the development of endocrine pathology in children. The modern data on the role of epigenetic influences in the early ontogenesis of unfavorable factors that violate the patterns of the formation of regulatory mechanisms during periods of critical development of fetal organs and systems and contribute to the delayed development of pathological conditions are considered. The mechanisms of the participation of melatonin in the regulation of metabolic processes and the key role of maternal melatonin in the formation of the circadian system of regulation in the fetus and in the protection of the genetic program of its morphofunctional development during pregnancy complications are presented. Melatonin, by controlling DNA methylation and histone modification, prevents changes in gene expression that are directly related to the programming of endocrine pathology in offspring. Deficiency and absence of the circadian rhythm of maternal melatonin underlies violations of the genetic program for the development of hormonal and metabolic regulatory mechanisms of the functional systems of the child, which determines the programming and implementation of endocrine pathology in early ontogenesis, contributing to its development in later life. The significance of this factor in the pathophysiological mechanisms of endocrine disorders determines a new approach to risk assessment and timely prevention of offspring diseases even at the stage of family planning. Full article
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