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Special Issue "Molecular Connection between the Endocrine System and Body Regulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Prof. Dr. Barbara Predieri
E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences of the Mother, Children and Adults - Pediatric Unit, University of Modena and Reggio Emilia, Modena, Italy
Interests: diabetes; obesity; cardiovascular disease; dyslipidemia; bone diseases; endocrine systems; endocrine disruptors; endocrine-related tumor and cancer

Special Issue Information

Dear Colleagues,

Communication within the human body involves the transmission of signals to control and coordinate actions in an effort to maintain homeostasis. One of the major organ systems responsible for providing these communication pathways is the endocrine system. In addition to the major endocrine glands, other organs of the body show endocrine function including the hypothalamus, heart, kidneys, gastrointestinal tract, and liver. Moreover, adipose tissue has long been known to produce hormones and pro-inflammatory cytokines while bone-derived hormones play an important role in metabolism. Disruption of the gut microbiota and both inflammatory and metabolic biomarkers affect neuroendocrine homeostasis and promote several peripheral endocrine system diseases.

In this Special Issue of IJMS, we wish to offer a platform for high-quality research and current review articles on the relationship between the endocrine system and body regulation. Moreover, we will highlight recent research and review the role of gut microbiota and metabolic and inflammatory biomarkers in the mechanisms underlying the development of endocrine diseases and their related complications.

Prof. Dr. Barbara Predieri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • appetite regulation
  • bone metabolism
  • cardiovascular disease
  • diabetes
  • endocrine system
  • endocrine-related diseases
  • growth and development
  • inflammatory cytokines
  • microbiota
  • obesity

Published Papers (1 paper)

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Open AccessArticle
Maternal Heat Stress Alters Expression of Genes Associated with Nutrient Transport Activity and Metabolism in Female Placentae from Mid-Gestating Pigs
Int. J. Mol. Sci. 2021, 22(8), 4147; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084147 - 16 Apr 2021
Viewed by 191
Placental insufficiency is a known consequence of maternal heat stress during gestation in farm animals. The molecular regulation of placentae during the stress response is little known in pigs. This study aims to identify differential gene expression in pig placentae caused by maternal [...] Read more.
Placental insufficiency is a known consequence of maternal heat stress during gestation in farm animals. The molecular regulation of placentae during the stress response is little known in pigs. This study aims to identify differential gene expression in pig placentae caused by maternal heat exposure during early to mid-gestation. RNA sequencing (RNA-seq) was performed on female placental samples from pregnant pigs exposed to thermoneutral control (CON; constant 20 °C; n = 5) or cyclic heat stress (HS; cyclic 28 to 33 °C; n = 5) conditions between d40 and d60 of gestation. On d60 of gestation, placental efficiency (fetal/placental weight) was decreased (p = 0.023) by maternal HS. A total of 169 genes were differentially expressed (FDR ≤ 0.1) between CON and HS placentae of female fetuses, of which 35 genes were upregulated and 134 genes were downregulated by maternal HS. The current data revealed transport activity (FDR = 0.027), glycoprotein biosynthetic process (FDR = 0.044), and carbohydrate metabolic process (FDR = 0.049) among the terms enriched by the downregulated genes (HS vs. CON). In addition, solute carrier (SLC)-mediated transmembrane transport (FDR = 0.008) and glycosaminoglycan biosynthesis (FDR = 0.027), which modulates placental stroma synthesis, were identified among the pathways enriched by the downregulated genes. These findings provide evidence that heat-stress induced placental inefficiency may be underpinned by altered expression of genes associated with placental nutrient transport capacity and metabolism. A further understanding of the molecular mechanism contributes to the identification of placental gene signatures of summer infertility in pigs. Full article
(This article belongs to the Special Issue Molecular Connection between the Endocrine System and Body Regulation)
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