Special Issue "Ligand Binding in Enzyme Systems"
Deadline for manuscript submissions: closed (15 February 2021).
Interests: Bioenergetics; Biophysics; Chemical Biology; Enzymology Kinetics; Molecular Medicine; Protein Chemistry Structural; Biology
Interests: enzyme kinetics; vitamin B6 metabolism; pyridoxal 5'-phosphate-dependent enzymes; bacterial transcriptional regulation; neonatal epileptic encephalopathy
Special Issues and Collections in MDPI journals
From a chemical point of view, the primary event in most biological processes is a second-order reaction, i. e., the reversible binding of a ligand to a specific target (protein, receptor, nucleic acid, or enzyme). In general, the binding dynamics may involve induced-fit or conformational selection mechanisms. In the world of enzymes, ligand binding, other than substrate binding, offers additional levels of complexity, whereby the enzyme may be regulated by feedback, product, and allosteric positive and negative modulation or may acquire new enzymatic activities or novel biological functions, as in moonlighting enzymes.
This Special Issue concentrates on the role of ligand binding to enzymes at the onset of the perturbation triggered by the ligand, both from thermodynamic and kinetic viewpoints. Original research articles and sharp up-to-date reviews on these and related topics are welcome in this Special Issue.
Prof. Francesco Malatesta
Dr. Roberto Contestabile
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- ligand binding
- allosteric enzymes
- enzyme regulation
- enzyme inhibition
- moonlighting enzymes
- steady-state kinetics
- pre-steady-state kinetics
- stopped-flow spectroscopy