Special Issue "Enzymes as Targets for Drug Development 2020"
Deadline for manuscript submissions: 31 July 2021.
Interests: biochemistry; enzymology; drug discovery; SELEX (Systematic Evolution of Ligands by Exponential enrichment); in vitro selection technique
Special Issues and Collections in MDPI journals
The most attractive targets for drug development are considered enzymes in the pharmaceutical community. Characterization of enzymes is, therefore, critical in understanding their reactions. Many analytical methods are needed to complete characterization such as purification, kinetics, protein stabilization, optimal conditions for pH, temperature, and ionic strength, subtract or product binding, ligand/inhibitor/protein interactions, three-dimensional structure, and conformational changes. Recently, in silico analysis has made a huge contribution to the enzyme characterization. Molecular docking and molecular dynamics should be included as major techniques. This Special Issue brings together a large number of intriguing subjects to promote ideas on enzymes as targets for drug development.
It is envisioned that the following topics would be included in the Special Issue.
Improvement of enzyme purification;
Development of novel inhibitors;
Investigation of enzyme mechanism;
Understanding enzyme conformation changes.
Dr. Sung-Kun (Sean) Kim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- enzyme kinetics
- enzyme-ligand or protein-protein interactions
- enzyme inhibitions
- enzyme purifications and optimal conditions
- enzyme structures
- enzyme computational analysis