Special Issue "Ephrin Receptors and Cancer"
Deadline for manuscript submissions: 31 October 2021.
Interests: apoptosis; metabolism; cytopathology; pathology; molecular pathology; immunohistochemistry
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The family of receptor tyrosine kinases (RTKs), ephrin receptors (EPHs), comprises 14 cell-bound members divided into two classes, A and B, based on their sequence similarity and binding affinity to their ligands, ephrins. In a similar manner, ephrins are also cell-bound proteins and include ephrin-A and ephrin-B classes. Nine class A EPHs (EPHA1-EPHA8, EPHA10) and five class B EPHs (EPHB1-EPHB4, EPHB6) preferentially bind five ephrin-A and three ephrin-B classes. The EPH/ephrin system is involved into key regulatory processes of human physiology: it highlights axon guidance and synaptic plasticity in the nervous system, as well as angiogenesis, vascular remodeling, and homeostasis of various tissues. In addition, this cell–cell communication system is implicated in several pathologic processes, including neurodegenerative disorders, viral infections, and cancer. Indeed, its deregulation affects tumor growth, progression, metastasis, and neovascularization by disrupting critical signaling transduction pathways. EPHs’ and ephrins’ aberrant expression characterizes not only the tumor cells but also the tumor microenvironment, where endothelial cells have mostly been investigated; this makes the EPH/ephrin system an appealing candidate for targeted intervention. EPHs’ upregulation in the pathogenesis of malignant transformation has been reported, suggesting their use as potential biomarkers and drug targets for various cancer types.
Prof. Stamatios E. Theocharis
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- ephrin receptors