Special Issue "The Role of Epoxygenated Fatty Acids and Soluble Epoxide Hydrolase in Metabolic Regulation"
Deadline for manuscript submissions: 30 September 2021.
Interests: metabolic diseases; obesity; type 2 diabetes; protein tyrosine phosphatases; protein kinases; hydrolases
Special Issues and Collections in MDPI journals
A growing body of evidence is highlighting the importance of arachidonic acid (AA) and its derivatives for human health and tissue homeostasis. AA metabolism provides an interesting link between obesity and its associated diseases and has been implicated in the occurrence and progression of both metabolic and non-metabolic diseases. Eicosanoids generated from cyclooxygenase- and lipoxygenase-mediated metabolism of AA are well-known bioactive lipids that promote and maintain inflammatory signaling cascades. Over the last two decades, there has been continued interest in therapeutically targeting these two predominantly pro-inflammatory pathways, while the latest identified branch of the AA cascade, known as the cytochrome P450 branch, offers underexploited features and novel therapeutic targets. Of particular interest, soluble epoxide hydrolase (sEH), previously known as cytosolic epoxide hydrolase, has emerged as a promising therapeutic target for a spectrum of diseases. sEH hydrolyzes epoxyeicosatrienoic acids (EETs) into dihydroxyeicosatrienoic acids. A growing body of evidence suggests that sEH inhibition, and therefore the stabilization of EETs, exhibits beneficial effects through the modulation of key signaling pathways important for maintaining cellular homeostasis. Notably, sEH genetic deficiency and pharmacological inhibition have been demonstrated to prevent and/or alleviate metabolic dysregulation through several mechanisms. The purpose of this Special Issue is to provide the current state of knowledge about the role of sEH and its metabolites in metabolic homeostasis. Additionally, this Special Issue will provide an updated overview of existing literature on the impact of therapeutically targeting sEH for the treatment and prevention of metabolic diseases.
Prof. Dr. Ahmed Bettaieb
Manuscript Submission Information
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- soluble epoxide hydrolase (sEH)
- epoxygenated fatty acids
- arachidonic acid (AA) and its derivatives
- AA metabolism
- metabolic diseases