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Special Issue "The Role of Epoxygenated Fatty Acids and Soluble Epoxide Hydrolase in Metabolic Regulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Ahmed Bettaieb
E-Mail Website
Guest Editor
Department of Nutrition, The University of Tennessee-Knoxville, Knoxville, TN 37996-1920, USA
Interests: metabolic diseases; obesity; type 2 diabetes; protein tyrosine phosphatases; protein kinases; hydrolases
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

A growing body of evidence is highlighting the importance of arachidonic acid (AA) and its derivatives for human health and tissue homeostasis. AA metabolism provides an interesting link between obesity and its associated diseases and has been implicated in the occurrence and progression of both metabolic and non-metabolic diseases. Eicosanoids generated from cyclooxygenase- and lipoxygenase-mediated metabolism of AA are well-known bioactive lipids that promote and maintain inflammatory signaling cascades. Over the last two decades, there has been continued interest in therapeutically targeting these two predominantly pro-inflammatory pathways, while the latest identified branch of the AA cascade, known as the cytochrome P450 branch, offers underexploited features and novel therapeutic targets. Of particular interest, soluble epoxide hydrolase (sEH), previously known as cytosolic epoxide hydrolase, has emerged as a promising therapeutic target for a spectrum of diseases. sEH hydrolyzes epoxyeicosatrienoic acids (EETs) into dihydroxyeicosatrienoic acids. A growing body of evidence suggests that sEH inhibition, and therefore the stabilization of EETs, exhibits beneficial effects through the modulation of key signaling pathways important for maintaining cellular homeostasis. Notably, sEH genetic deficiency and pharmacological inhibition have been demonstrated to prevent and/or alleviate metabolic dysregulation through several mechanisms. The purpose of this Special Issue is to provide the current state of knowledge about the role of sEH and its metabolites in metabolic homeostasis. Additionally, this Special Issue will provide an updated overview of existing literature on the impact of therapeutically targeting sEH for the treatment and prevention of metabolic diseases.

Prof. Dr. Ahmed Bettaieb
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • soluble epoxide hydrolase (sEH)
  • epoxygenated fatty acids
  • arachidonic acid (AA) and its derivatives
  • AA metabolism
  • obesity
  • metabolic diseases

Published Papers

This special issue is now open for submission.
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