Regulation of Erythropoiesis 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 August 2022) | Viewed by 5422
Special Issue Editor
Interests: transcriptional regulation; transcription factors; chromatin remodeling complexes; cell fate decision; erythropoiesis; cancer stem cells; anticancer drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Approximately 84% of the cells in the human body are red blood cells. Erythropoiesis is the complex process that produces mature red blood cells (erythrocytes) from erythropoietic stem cells, and mature red blood cells in mammals uniquely lack a cell nucleus and most organelle, with some exceptions in some salamanders and fish. Genetic diseases, such as sickle cell anemia and hereditary persistence of fetal hemoglobin (HPFH) and erythroleukemia, have been studied as a model for gene expression control and for molecular genetic understanding and treatment development. However, although considerable advances in the understanding of erythropoiesis and hemoglobin switching have occurred, the fundamental molecular mechanism of the regulation of erythropoiesis and globin switching is still not understood
This Special Issue on the regulation of erythropoiesis will include a selection of original papers and reviews focused on genetic and cellular bases and molecular mechanisms of erythroid differentiation and globin switching, including epigenetic connections between the gene regulatory network and chromatin dynamics, cell signaling, recent progress in single cell genomics, and various new pathophysiologic mechanisms.
Prof. Dr. Chul Geun Kim
Guest Editor
Manuscript Submission Information
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Keywords
- erythropoiesis
- hemoglobin switching
- gene regulatory network
- epigenetics
- chromatin dynamics
- cell signaling
- single cell genomics
- pathophysiologic mechanisms
