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Special Issue "Esterases in the Circulatory System: Structure, Function, Activity Modulation and Involvement in Pathology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 August 2021.

Special Issue Editor

Prof. Dr. Marc A. Ilies
E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA, USA
Interests: medicinal chemistry; chemical biology; drug and nucleic acid delivery systems

Special Issue Information

Dear Colleagues,

The circulatory system contains a plethora of esterases, which are enzymes specialized in cleaving various esters that are normally and recurrently present in circulation as part of the body homeostasis or that can appear transiently due to diet, various dysfunction or diseases. Due to the large range of lipophilicity of the substrates that can be normally or potentially present in the bloodstream, the circulatory system displays a wide range of esterases, either solubilized in blood/plasma, attached on the blood vessel walls and/or encapsulated into various cells present in the bloodstream (red blood cells, platelets, leukocytes, etc.). The proposed thematic issue aims to detail their structure and mechanism of action as a function of the lipophilicity of the esters processed and their physiologic role(s) in the circulatory system. Special emphasis will be placed on the involvement of different circulatory system esterases in diseases and their activity modulation (inhibition/activation) for therapeutic purposes.

Prof. Dr. Marc A. Ilies
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • esterases and lipases
  • circulatory system
  • blood, plasma, blood vessels, figurative elements of blood
  • physiopathology
  • structure and catalysis mechanism
  • substrate selectivity
  • activity assays
  • inhibition and activation
  • drugs in clinical use and under development

Published Papers

This special issue is now open for submission.
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