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Special Issue "Focus on Exosome-Based Cell-Cell Communication in Health and Disease II"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editors

Prof. Dr. Riccardo Alessandro
Website
Guest Editor
Dipartimento di Biopatologia e Biotecnologie Mediche, Università degli studi di Palermo, sezione di Biologia e Genetica, Palermo, Italy
Interests: cancer biology; exosomes; cancer cells; cell migration; cell adhesion; endothelial cells; cell biology; angiogenesis; signal transduction; cancer research; metastasis; tumor invasion
Special Issues and Collections in MDPI journals
Dr. Aurelio Lorico
Website
Guest Editor
Department of Pathology, College of Medicine, Roseman University of Health Sciences, Las Vegas, Nevada, USA
Interests: cancer biology; exosomes; cancer cells; cell migration; cell adhesion; cell biology; Prominin-1; signal transduction; cancer research; metastasis; tumor invasion
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last few years, a new and sophisticated mechanism of cell–cell communication, based on exosomes, has been described.

Exosomes are specialized vesicles of endosomal origin, released into the extracellular space by most cell types under physiological and pathological conditions. It has been widely described that these vesicles contain mRNAs, microRNAs, long non-coding RNAs, lipids, and proteins, and that they can deliver these molecules among different cell types, thus affecting the phenotype of target cells.

Several studies have highlighted the role of exosomes in modulating cancer development and metastatic niche formation, as well as in contributing to neurological, cardiological, and rheumatological diseases. Due to their specific cell tropism, a peculiar property of these vesicles is the possibility to be engineered in order to modify their content, introducing siRNAs, shRNAs, proteins, and drugs.

This Special Issue will discuss the recent advances in the field of exosomes as messengers of intercellular communication in both physiological and pathological conditions, pointing out the potential use of these nanovesicles for the delivery of therapeutic agents.

Prof. Dr. Riccardo Alessandro
Dr. Aurelio Lorico
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exosomes
  • extracellular vesicles
  • cell–cell signaling
  • cancer
  • biomarkers
  • metastatic niche
  • cardiovascular diseases
  • neurological diseases

Published Papers (1 paper)

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Review

Open AccessReview
Large Extracellular Vesicles—A New Frontier of Liquid Biopsy in Oncology
Int. J. Mol. Sci. 2020, 21(18), 6543; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186543 - 07 Sep 2020
Cited by 1
Abstract
Extracellular Vesicles (EVs) are emerging as pivotal elements in cancer. Many studies have focused on the role of Small- (S)-EVs but in recent years Large-(L)-EVs have progressively gained increasing interest due to their peculiar content and functions. Tumor-derived L-EVs carry a lot of [...] Read more.
Extracellular Vesicles (EVs) are emerging as pivotal elements in cancer. Many studies have focused on the role of Small- (S)-EVs but in recent years Large-(L)-EVs have progressively gained increasing interest due to their peculiar content and functions. Tumor-derived L-EVs carry a lot of oncogenic proteins, nucleic acids and lipids to recipient cells and are involved in the reshaping of the tumor microenvironment as well as in the metabolic rewiring and the promotion of the pro-metastatic attitude of cancer cells. Several techniques have been developed for the isolation of L-EVs and commercial kits are also available for efficient and easy recovery of these vesicles. Also, the improvement in DNA sequencing and “omics sciences” profoundly changed the way to analyze and explore the molecular content of L-EVs, thus providing novel and potentially useful cancer biomarkers. Herein, we review the most recent findings concerning the role of L-EVs in cancer and discuss their possible use in oncology as “liquid biopsy” tools as compared to the other classes of EVs. Full article
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