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Special Issue "Cell Fate Decisions in Neural Development"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Dr. Chaya Kalcheim
E-Mail Website
Guest Editor
Department of Medical Neurobiology, Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel
Interests: neural crest; neural tube; roof plate, somite; mesoderm; myogenesis; peripheral nervous system; cell migration; epithelial-to mesenchymal transition; neuronal specification; developmental neurobiology; developmental biology; avian embryo

Special Issue Information

Dear Colleagues,

The large diversity of cell types that set up the complexity of the central and peripheral branches of the nervous system originates from small groups of progenitors during embryonic development. The combinatorial expression of specific genes that define a given cell identity is controlled by interactions between signaling proteins, transcription factors, and epigenetic mechanisms.

Recent advances in methodologies addressing these diverse levels of regulation have opened new opportunities to answer classical questions of when and how progenitors adopt their final identity and turn into functionally distinct cells. It is the combination between this emerging, large-scale basis of knowledge, and established gain and loss of function approaches that will impact the field in the coming years.

The scope of this collection will cover cellular and molecular mechanisms leading to the acquisition of specific identities of progenitors issued from the neural tube and neural crest in vertebrate embryos. This includes interactions at the signaling, transcriptional, and translational levels of regulation. Studies addressing these questions that implement both in vivo models as well as in vitro approaches based on embryonic stem cells or induced pluripotent stem cells will be welcome.

Prof. Dr. Chaya Kalcheim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell specification
  • cell lineage
  • cell-cell interactions
  • neural tube
  • neural crest
  • neuronal development
  • glial development
  • gene regulatory networks
  • gene editing
  • pattern formation
  • morphogenesis

Published Papers

This special issue is now open for submission.
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