Dear Colleagues,

One of the important scientific subjects that requires a serious reconsideration is in regard to the roles fatty acids play in the physiology and pathology of humans. New data have shown that sex-dependent differences between men and women in physical performances, rates of aging, and longevity are associated with the differences in fatty acids catabolism. The highest rates of ROS production were found to occur during mitochondrial β-oxidation of fatty acids in the heart and skeletal muscles. In the brain, astrocytes utilize fatty acids for supplying neurons with lactate and neuromediators, and recently it was found that neuronal mitochondria perfectly well oxidize fatty acids in the presence of glutamate and metabolites of the TCA cycle. Of particular importance for understanding the mechanisms of human aging and senile diseases is the study of the metabolic syndrome, which is associated with the transition of men and women to the post-reproductive stage of human ontogenesis. The proposed Special Issue will publish experimental data and reviews of researchers working in the related fields.

Dr. Alexander Panov
Guest Editor

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• aging
• fatty acids
• metabolic syndrome
• mitochondria
• ontogenesis
• oxidative stress
• ROS
• sex diversity