Special Issue "Molecular Basis of Fertility Preservation and Restoration 3.0"
Deadline for manuscript submissions: closed (31 August 2021).
Interests: male infertility; male fertility preservation; in vitro development of spermatogenesis; chemotherapy/irradiation and male infertility; cytokines/growth factors in the testis; acute myeloid leukemia and male infertility; rhree-dimension (3D) in vitro culture systems and spermatogenesis
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Fertility preservation, on both the male and female sides, is an exciting field, especially considering the urgent current need to find methods that allow parenthood with one’s own genetic background when gonadotoxic therapies risking permanent infertility are applied or when a genetic condition responsible for infertility or loss of fertility over time is present.
Numerous approaches to preserve and restore fertility are under investigation and, with the perspective of a clinical application, a better understanding of current achievements at the cellular and molecular levels is needed. Some strategies rely on the use of cryopreserved gonadal tissue or cells, such as in vitro germ cell maturation or cell and tissue transplantation, while others focus on the use of alternative sources of stem cells or on protecting in situ germ cells from gonadotoxicity. To facilitate preclinical studies, improved knowledge on molecular markers for developing germ cells could prove useful.
This Special Issue therefore focuses on current developments in the field of fertility preservation and on perspectives for fertility restoration in humans. Both original research articles and comprehensive review papers are welcomed.
Prof. Dr. Mahmoud Huleihel
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- fertility preservation
- stem cells
- ovarian tissue
- in vitro maturation
- germ cells
- single-cell transcriptome
- induced pluripotent stem cells
- organ-on-chip (OoC)
- microfluidic systems
- germ cell transplantation