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Special Issue "Molecular Basis of Fertility Preservation and Restoration 3.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 August 2021).

Special Issue Editor

Prof. Dr. Mahmoud Huleihel
E-Mail Website
Guest Editor
The Shraga Segal Department of Microbiology, Immunology, and Genetics and The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Interests: male infertility; male fertility preservation; in vitro development of spermatogenesis; chemotherapy/irradiation and male infertility; cytokines/growth factors in the testis; acute myeloid leukemia and male infertility; rhree-dimension (3D) in vitro culture systems and spermatogenesis
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Special Issue Information

Dear Colleagues,

Fertility preservation, on both the male and female sides, is an exciting field, especially considering the urgent current need to find methods that allow parenthood with one’s own genetic background when gonadotoxic therapies risking permanent infertility are applied or when a genetic condition responsible for infertility or loss of fertility over time is present.

Numerous approaches to preserve and restore fertility are under investigation and, with the perspective of a clinical application, a better understanding of current achievements at the cellular and molecular levels is needed. Some strategies rely on the use of cryopreserved gonadal tissue or cells, such as in vitro germ cell maturation or cell and tissue transplantation, while others focus on the use of alternative sources of stem cells or on protecting in situ germ cells from gonadotoxicity. To facilitate preclinical studies, improved knowledge on molecular markers for developing germ cells could prove useful.

This Special Issue therefore focuses on current developments in the field of fertility preservation and on perspectives for fertility restoration in humans. Both original research articles and comprehensive review papers are welcomed.

Prof. Dr. Mahmoud Huleihel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fertility preservation
  • infertility
  • testis
  • ovary
  • spermatogonia
  • stem cells
  • ovarian tissue
  • in vitro maturation
  • metabolism
  • transplantation
  • miRNA
  • germ cells
  • single-cell transcriptome
  • induced pluripotent stem cells
  • organ-on-chip (OoC)
  • organoids
  • microfluidic systems
  • germ cell transplantation
  • epigenetics

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Published Papers (2 papers)

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Review

Review
The Role of Noncoding RNA in the Pathophysiology and Treatment of Premature Ovarian Insufficiency
Int. J. Mol. Sci. 2021, 22(17), 9336; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179336 - 28 Aug 2021
Viewed by 369
Abstract
Premature ovarian insufficiency (POI) is defined as a loss of ovarian function before the age of 40 years, with a prevalence rate estimated at approximately 1%. It causes infertility and is related to serious long-term health consequences, including reduced life expectancy, increased cardiovascular [...] Read more.
Premature ovarian insufficiency (POI) is defined as a loss of ovarian function before the age of 40 years, with a prevalence rate estimated at approximately 1%. It causes infertility and is related to serious long-term health consequences, including reduced life expectancy, increased cardiovascular risk, decreased bone mineral density and neurological disorders. There is currently no effective therapy for POI that is widely available in clinical practice; therefore, the treatment of patients with POI is based on hormone replacement therapy. One of the recent advances in the understanding of the pathophysiology of POI has been the role of microRNAs (miRNAs) and other noncoding RNAs (ncRNAs) in the disease. Moreover, intensive research on human folliculogenesis and reproductive biology has led to the development of novel promising therapeutic strategies with the use of exosomal miRNAs derived from mesenchymal stem cells to restore ovarian function in POI patients. This narrative review focuses on the new studies concerning the role of ncRNAs in the pathogenesis of POI, together with their potential as biomarkers of the disease and targets for therapy. Full article
(This article belongs to the Special Issue Molecular Basis of Fertility Preservation and Restoration 3.0)
Review
In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives
Int. J. Mol. Sci. 2021, 22(7), 3785; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073785 - 06 Apr 2021
Cited by 2 | Viewed by 907
Abstract
Development of early follicles, especially the activation of primordial follicles, is strictly modulated by a network of signaling pathways. Recent advance in ovarian physiology has been allowed the development of several therapies to improve reproductive outcomes by manipulating early folliculogenesis. Among these, in [...] Read more.
Development of early follicles, especially the activation of primordial follicles, is strictly modulated by a network of signaling pathways. Recent advance in ovarian physiology has been allowed the development of several therapies to improve reproductive outcomes by manipulating early folliculogenesis. Among these, in vitro activation (IVA) has been recently developed to extend the possibility of achieving genetically related offspring for patients with premature ovarian insufficiency and ovarian dysfunction. This method was established based on basic science studies of the intraovarian signaling pathways: the phosphoinositide 3-kinase (PI3K)/Akt and the Hippo signaling pathways. These two pathways were found to play crucial roles in folliculogenesis from the primordial follicle to the early antral follicle. Following the results of rodent experiments, IVA was implemented in clinical practice. There have been multiple recorded live births and ongoing pregnancies. Further investigations are essential to confirm the efficacy and safety of IVA before used widely in clinics. This review aimed to summarize the published literature on IVA and provide future perspectives for its improvement. Full article
(This article belongs to the Special Issue Molecular Basis of Fertility Preservation and Restoration 3.0)
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