Special Issue "Advances in Biological Function of Fibrinogen and Fibrin"
Deadline for manuscript submissions: closed (30 April 2020).
Interests: endothelium; microbial infection; inflammation; cancer; coagulation; vascular remodeling
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Since its discovery over three centuries ago, studies on fibrinogen and fibrin (fibrin(ogen)) have led to remarkable advances in structure–function analysis, as well as evidence for the involvement of this versatile biological molecule in multiple physiological and pathological scenarios, including cardiovascular ailments, inflammation, infection, tumour growth and metastasis, and neurological disorders. Interactions of fibrin(ogen) with plasma proteins and receptors on the platelets, leukocytes, endothelial cells, and other cells, regulate a multitude of signalling pathways as well as their downstream consequences. Alterations in the levels and/or functions of fibrin(ogen) increase the risk of haemorrhage, thrombosis, infection, inflammation, and many other disease states. Genetic and pharmacologic approaches have further ascertained the important contributions of fibrinogen during local or systemic inflammation. A collection of cellular and molecular analyses further project fibrin(ogen) as a signalling molecule, determining the balance between haemostasis and thrombosis, coagulation and fibrosis, and eventually life and death. Continued efforts to enhance our understanding of the roles of fibrinogen and fibrin in these processes are likely to advance treatment options and the prevention of many human diseases.
This Special Issue on “Advances in Biological Functions of Fibrinogen and Fibrin” invites original research, reviews, and perspectives focused on all aspects of fibrinogen and fibrin, and aims to provide a comprehensive summary of the ongoing biomedical research on the roles of fibrin(ogen) in thrombosis, haemostasis, and other diseases.
Prof. Dr. Abha Sahni
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.