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Special Issue "Flavonoids and Other Polyphenols in Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Justyna Godos
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Guest Editor
Oasi Research Institute - IRCCS, Troina, Italy
Interests: flavonoids; polyphenols; polyphenol-rich foods; mental health; nutritional epidemiology
Special Issues and Collections in MDPI journals
Prof. Dr. Fabio Galvano
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Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Interests: polyphenols; Mediterranean diet; coffee; functional foods; cardiovascular diseases; cancer; nutritional epidemiology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, we observed a rise in the prevalence of non-communicable diseases such as cardiovascular diseases, cancer, and neurodegenerative diseases underlined by subclinical inflammation and oxidative stress. Many factors might have contributed to this phenomenon, including dietary, social, and environmental factors. Certainly, a transition from traditional dietary patterns (i.e., Mediterranean diet) characterized by a high intake of polyphenol-rich foods to Western-like dietary patterns characterized by a high intake of processed foods deprived from healthy nutrients like polyphenols played a role in the higher prevalence of chronic diseases.

Therefore, the aim of this Special Issue is to increase evidence on the effects of polyphenols and polyphenol-rich foods on non-communicable diseases by improving our understanding of their beneficial mechanisms, which in turn may contribute to the development of novel therapies.

We welcome the submission of original contributions, including experimental studies, clinical trials, and observational studies, as well as reviews of published literature exploring and summarizing the effect of polyphenol-rich foods, individual polyphenols, and their metabolites toward non-communicable diseases, including cardiovascular diseases, cancer, and neurodegenerative diseases.

Dr. Justyna Godos
Prof. Dr. Fabio Galvano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • flavonoids
  • polyphenols
  • polyphenol-rich foods
  • polyphenol-rich beverages
  • nutrition
  • diet
  • chronic diseases
  • cardiovascular diseases
  • neurodegenerative diseases
  • cancer

Published Papers (2 papers)

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Open AccessArticle
Rutin Modulates MAPK Pathway Differently from Quercetin in Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy
Int. J. Mol. Sci. 2021, 22(10), 5063; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105063 - 11 May 2021
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Abstract
Rutin is a flavonoid with antioxidant property. It has been shown to exert cardioprotection against cardiomyocyte hypertrophy. However, studies regarding its antihypertrophic property are still lacking, whether it demonstrates similar antihypertrophic effect to its metabolite, quercetin. Hence, this study aimed to investigate the [...] Read more.
Rutin is a flavonoid with antioxidant property. It has been shown to exert cardioprotection against cardiomyocyte hypertrophy. However, studies regarding its antihypertrophic property are still lacking, whether it demonstrates similar antihypertrophic effect to its metabolite, quercetin. Hence, this study aimed to investigate the effects of both flavonoids on oxidative stress and mitogen-activated protein kinase (MAPK) pathway in H9c2 cardiomyocytes that were exposed to angiotensin II (Ang II) to induce hypertrophy. Cardiomyocytes were exposed to Ang II (600 nM) with or without quercetin (331 μM) or rutin (50 μM) for 24 h. A group given vehicle served as the control. The concentration of the flavonoids was chosen based on the reported effective concentration to reduce cell hypertrophy or cardiac injury in H9c2 cells. Exposure to Ang II increased cell surface area, intracellular superoxide anion level, NADPH oxidase and inducible nitric oxide synthase activities, and reduced cellular superoxide dismutase activity and nitrite level, which were similarly reversed by both rutin and quercetin. Rutin had no significant effects on phosphorylated proteins of extracellular signal-related kinases (ERK1/2) and p38 but downregulated phosphorylated c-Jun N-terminal kinases (JNK1/2), which were induced by Ang II. Quercetin, on the other hand, had significantly downregulated the phosphorylated proteins of ERK1/2, p38, and JNK1/2. The quercetin inhibitory effect on JNK1/2 was stronger than the rutin. In conclusion, both flavonoids afford similar protective effects against Ang II-induced cardiomyocyte hypertrophy, but they differently modulate MAPK pathway. Full article
(This article belongs to the Special Issue Flavonoids and Other Polyphenols in Health and Disease)
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Review

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Open AccessReview
Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
Int. J. Mol. Sci. 2021, 22(4), 1668; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22041668 - 07 Feb 2021
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Abstract
Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. [...] Read more.
Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a polyphenol-rich diet can slow the progression of or reverse HF in humans is not known. To date, in vitro and in vivo studies have reported on the protective role of polyphenols in HF. In this review, we will discuss the major mechanisms by which polyphenols mitigate HF in vitro and in vivo, including (1) reduced cardiac inflammation and oxidative stress, (2) reduced mitochondrial dysfunction, (3) improved Ca2+ homeostasis, (4) increased survival signaling, and (5) increased sirtuin 1 activity. Full article
(This article belongs to the Special Issue Flavonoids and Other Polyphenols in Health and Disease)
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