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Special Issue "Gangliosides: Modes of Action and Cell Fates II"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Koichi Furukawa
E-Mail Website
Guest Editor
Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan
Interests: glycosphingolipids; neuronal cell; glioma cell; cancer; glycosylation; gangliosides; inflammation; neurodegeneration

Special Issue Information

Dear Colleagues,

Gangliosides, sialic acid-containing glycosphingolipids, are mainly expressed on the cell membrane in vertebrates. The structure of the carbohydrate moieties varies depending on the development and differentiation states of tissues and cells. In particular, the polymorphic alteration of gangliosides along with the development and differentiation of nervous tissues has suggested their roles in the organogenesis of the nervous system. On the other hand, some gangliosides are considered to be cancer-associated antigens and have been used as tumor markers and targets for antibody therapy. Since cDNAs for ganglioside synthases were isolated, the genetic modification of ganglioside expression in cultured cells and experimental animals has enabled us to substantially elucidate the roles of gangliosides in cancers and the nervous system. The main findings can be summarized as follows: (i) Gangliosides play a pivotal role in the maintenance of the integrity of the nervous system and also in the repair of damaged nerves; (ii) Gangliosides are important for the architecture and function of membrane microdomains such as lipid rafts; and (iii) Gangliosides regulate cell signals in lipid rafts based on the interaction with ganglioside-recognizing molecules, influencing the cell fate. The formation of molecular clusters around gangliosides is now attracting the attention of many researchers in this field. We would like to focus on the modes of action of gangliosides and resulting cell fates to further understand the role of these molecules in the human body. This Special Issue calls for original research articles, reviews, and perspectives that address our current knowledge and progress in the research on gangliosides, focusing on their modes of action, and their influence on cell fate. In the 2nd version, articles regarding regulatory systems of ganglioside behaviors and basic analysis aiming application of ganglioside functions in clinical will be included.

Prof. Dr. Koichi Furukawa
Guest Editor

Manuscript Submission Information

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Keywords

  • acidic glycosphingolipids 
  • microdomains and lipid rafts 
  • molecular complex formation 
  • regulation of signaling 
  • cell–cell interaction 
  • recognition and interaction with glycolipids 
  • proliferation and differentiation 
  • activation and inactivation

Published Papers (1 paper)

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Review

Open AccessReview
Roles of Gangliosides in Hypothalamic Control of Energy Balance: New Insights
Int. J. Mol. Sci. 2020, 21(15), 5349; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155349 - 28 Jul 2020
Cited by 2 | Viewed by 520
Abstract
Gangliosides are essential components of cell membranes and are involved in a variety of physiological processes, including cell growth, differentiation, and receptor-mediated signal transduction. They regulate functions of proteins in membrane microdomains, notably receptor tyrosine kinases such as insulin receptor (InsR) and epidermal [...] Read more.
Gangliosides are essential components of cell membranes and are involved in a variety of physiological processes, including cell growth, differentiation, and receptor-mediated signal transduction. They regulate functions of proteins in membrane microdomains, notably receptor tyrosine kinases such as insulin receptor (InsR) and epidermal growth factor receptor (EGFR), through lateral association. Studies during the past two decades using knockout (KO) or pharmacologically inhibited cells, or KO mouse models for glucosylceramide synthase (GCS; Ugcg), GM3 synthase (GM3S; St3gal5), and GD3 synthase (GD3S; St8sia1) have revealed essential roles of gangliosides in hypothalamic control of energy balance. The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway. Studies of GM3S KO cells have shown that the extracellular signal-regulated kinase (ERK) pathway, downstream of the LepR signaling pathway, is also modulated by gangliosides. Recent studies have revealed crosstalk between the LepR signaling pathway and other receptor signaling pathways (e.g., InsR and EGFR pathways). Gangliosides thus have the ability to modulate the effects of leptin by regulating functions of such receptors, and by direct interaction with LepR to control signaling. Full article
(This article belongs to the Special Issue Gangliosides: Modes of Action and Cell Fates II)
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