Special Issue "Gangliosides: Modes of Action and Cell Fates II"
Deadline for manuscript submissions: 31 October 2021.
Gangliosides, sialic acid-containing glycosphingolipids, are mainly expressed on the cell membrane in vertebrates. The structure of the carbohydrate moieties varies depending on the development and differentiation states of tissues and cells. In particular, the polymorphic alteration of gangliosides along with the development and differentiation of nervous tissues has suggested their roles in the organogenesis of the nervous system. On the other hand, some gangliosides are considered to be cancer-associated antigens and have been used as tumor markers and targets for antibody therapy. Since cDNAs for ganglioside synthases were isolated, the genetic modification of ganglioside expression in cultured cells and experimental animals has enabled us to substantially elucidate the roles of gangliosides in cancers and the nervous system. The main findings can be summarized as follows: (i) Gangliosides play a pivotal role in the maintenance of the integrity of the nervous system and also in the repair of damaged nerves; (ii) Gangliosides are important for the architecture and function of membrane microdomains such as lipid rafts; and (iii) Gangliosides regulate cell signals in lipid rafts based on the interaction with ganglioside-recognizing molecules, influencing the cell fate. The formation of molecular clusters around gangliosides is now attracting the attention of many researchers in this field. We would like to focus on the modes of action of gangliosides and resulting cell fates to further understand the role of these molecules in the human body. This Special Issue calls for original research articles, reviews, and perspectives that address our current knowledge and progress in the research on gangliosides, focusing on their modes of action, and their influence on cell fate. In the 2nd version, articles regarding regulatory systems of ganglioside behaviors and basic analysis aiming application of ganglioside functions in clinical will be included.Prof. Dr. Koichi Furukawa
Manuscript Submission Information
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- acidic glycosphingolipids
- microdomains and lipid rafts
- molecular complex formation
- regulation of signaling
- cell–cell interaction
- recognition and interaction with glycolipids
- proliferation and differentiation
- activation and inactivation