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Gender-Biased Molecular Targets in Cancer Biology
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Gender-Biased Molecular Targets in Cancer Biology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 15567

Special Issue Editors

Prof. Dr. Sang Geon Kim

E-Mail Website
Guest Editor
College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Kyeonggi-do, Republic of Korea
Interests: diabetes; complications; NASH; fibrosis; new drug development; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Aree Moon

E-Mail Website
Guest Editor
College of Pharmacy, Duksung Women’s University, Seoul 132‐714, Korea
Interests: molecular oncology; breast cancer; Ras signaling; cell invasion; tumor microenvironment

Special Issue Information

Dear Colleagues,

A Special Issue on the hot topic "Gender-Biased Molecular Targets in Cancer Biology" is being prepared for the journal IJMS. Gender-biased disparities have been observed in many types of cancers. Accumulating evidence suggests that genetic and molecular differences between male and female cancers may contribute to the gender-biased disparities in incidence and mortality of cancers. Identification of the molecular differences based on gender is important for early diagnosis of cancer, prediction of cancer prognosis, and determination of response to specific therapies. The identified molecules may represent potential candidates as gender-specific molecular targets in cancer biology. These studies will provide molecular insights into the impact of gender on cancers, suggesting strategies for gender-biased therapy against  cancers. Original manuscripts and reviews dealing with the gender-specific molecules in cancer biology and therapy are very welcome from outstanding experts of the topic.

Prof. Dr. Sang Geon Kim
Prof. Dr. Aree Moon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gender difference
  • cancer
  • sex hormone
  • chemotherapy
  • molecular targets
  • gene expression

Published Papers (4 papers)

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Research

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11 pages, 2569 KiB  
Article
Sex Chromosomes Are Severely Disrupted in Gastric Cancer Cell Lines
by Sooeun Oh, Kyoungmi Min, Myungshin Kim and Suk Kyeong Lee
Int. J. Mol. Sci. 2020, 21(13), 4598; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21134598 - 28 Jun 2020
Cited by 4 | Viewed by 5792
Abstract
Sex has not received enough attention as an important biological variable in basic research, even though the sex of cells often affects cell proliferation, differentiation, apoptosis, and response to stimulation. Knowing and considering the sex of cells used in basic research is essential [...] Read more.
Sex has not received enough attention as an important biological variable in basic research, even though the sex of cells often affects cell proliferation, differentiation, apoptosis, and response to stimulation. Knowing and considering the sex of cells used in basic research is essential as preclinical and clinical studies are planned based on basic research results. Cell lines derived from tumor have been widely used for proof-of-concept experiments. However, cell lines may have limitations in testing the effect of sex on cell level, as chromosomal abnormality is the single most characteristic feature of tumor. To examine the status of sex chromosomes in a cell line, 12 commercially available gastric carcinoma (GC) cell lines were analyzed using several different methods. Loss of Y chromosome (LOY) accompanied with X chromosome duplication was found in three (SNU-484, KATO III, and MKN-1) out of the six male-derived cell lines, while one cell line (SNU-638) showed at least partial deletion in the Y chromosome. Two (SNU-5 and MKN-28) out of six female-derived cell lines showed a loss of one X chromosome, while SNU-620 gained one extra copy of the X chromosome, resulting in an XXX karyotype. We found that simple polymerase chain reaction (PCR)-based sex determination gives a clue for LOY for male-derived cells, but it does not provide detailed information for the gain or loss of the X chromosome. Our results suggest that carefully examining the sex chromosome status of cell lines is necessary before using them to test the effect of sex on cell level. Full article
(This article belongs to the Special Issue Gender-Biased Molecular Targets in Cancer Biology)
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Review

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17 pages, 1245 KiB  
Review
Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer
by Ji-Won Heo, Sung-Eun Kim and Mi-Kyung Sung
Int. J. Mol. Sci. 2021, 22(3), 1253; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031253 - 27 Jan 2021
Cited by 17 | Viewed by 3895
Abstract
Cancer is the second leading cause of death worldwide, with 9.6 million people estimated to have died of cancer in 2018. Excess body fat deposition is a risk factor for many types of cancer. Men and women exhibit differences in body fat distribution [...] Read more.
Cancer is the second leading cause of death worldwide, with 9.6 million people estimated to have died of cancer in 2018. Excess body fat deposition is a risk factor for many types of cancer. Men and women exhibit differences in body fat distribution and energy homeostasis regulation. This systematic review aimed to understand why sex disparities in obesity are associated with sex differences in the incidence of gastrointestinal cancers. Cancers of the esophagus, liver, and colon are representative gastrointestinal cancers, and obesity is a convincing risk factor for their development. Numerous epidemiological studies have found sex differences in the incidence of esophageal, liver, and colorectal cancers. We suggest that these sexual disparities are partly explained by the availability of estrogens and other genetic factors regulating inflammation, cell growth, and apoptosis. Sex differences in gut microbiota composition may contribute to differences in the incidence and phenotype of colorectal cancer. To establish successful practices in personalized nutrition and medicine, one should be aware of the sex differences in the pathophysiology and associated mechanisms of cancer development. Full article
(This article belongs to the Special Issue Gender-Biased Molecular Targets in Cancer Biology)
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13 pages, 290 KiB  
Review
Urobiome in Gender—Related Diversities of Bladder Cancer
by Konrad Bilski, Jakub Dobruch, Mieszko Kozikowski, Michał A. Skrzypczyk, Maciej Oszczudłowski and Jerzy Ostrowski
Int. J. Mol. Sci. 2020, 21(12), 4488; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124488 - 24 Jun 2020
Cited by 17 | Viewed by 2968
Abstract
Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular [...] Read more.
Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, another related concept which has been speculated to contribute to gender diversities in BC is the role of urinary pathogens in bladder carcinogenesis. Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that perturbation in the microbiome is associated with various human diseases. The aim of this review is to comprehensively analyze the current literature according to sex-related differences in the microbiome composition in BC. Full article
(This article belongs to the Special Issue Gender-Biased Molecular Targets in Cancer Biology)
11 pages, 650 KiB  
Review
Gender Predilection in Sporadic Parathyroid Adenomas
by Maria P. Yavropoulou, Athanasios D. Anastasilakis, Argyro Panagiotakou, Evanthia Kassi and Polyzois Makras
Int. J. Mol. Sci. 2020, 21(8), 2964; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082964 - 22 Apr 2020
Cited by 4 | Viewed by 2518
Abstract
Primary hyperparathyroidism is a common endocrinopathy that is mainly caused by benign parathyroid adenomas. The frequency, clinical presentation and complications of the disease show significant differences between genders, with the majority of cases being reported in postmenopausal women. Due to this gender predilection, [...] Read more.
Primary hyperparathyroidism is a common endocrinopathy that is mainly caused by benign parathyroid adenomas. The frequency, clinical presentation and complications of the disease show significant differences between genders, with the majority of cases being reported in postmenopausal women. Due to this gender predilection, several studies have investigated the role of sex hormones in the pathogenesis of the disease and their potential use as targets for optimal and gender-specific management. Epigenetic mechanisms that regulate gene transcription may also contribute to these differences between genders. In this review, we outline what is currently known regarding the role of sex hormones and the recent data on the role of non-coding RNAs in the differences between genders in primary hyperparathyroidism due to sporadic parathyroid adenomas. Full article
(This article belongs to the Special Issue Gender-Biased Molecular Targets in Cancer Biology)
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