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Special Issue "Gender Related Molecular Mechanisms in Neurological Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (30 April 2021).

Special Issue Editor

Dr. Paolo Ragonese
E-Mail Website
Guest Editor
Università degli Studi di Palermo, Palermo, Italy
Interests: neurological disorders; neuroepidemiology; multiple scleorsis

Special Issue Information

Dear Colleagues,

Sex differences represent key issues in understanding clues of pathological mechanisms in neurological diseases. A relevant amount of studies have been performed in the past with the aim of investigating how molecular differences related to sex dependent aspects could shed some light to better understand aetiology and pathological mechanisms of neurological diseases. Sex differences have been reported for instance in several molecular and biochemical pathways (like oxidative stress). Oxidative stress mechanisms are reported to be higher in men than in women. Hormonal aspects have been usually considered the major drivers of sex differences in neurolgical diseases but, more recently, other pathways such as post genomic or epigenomic modification seem to give a considerable contribution.

The purpose of this Special Issue of IJMS is to explore how sex and gender issues may act in influencing molecular pathways of neurological disorders and of neurodegeneration, in order to understand clues about the pathology underlying neurodegenerative processes. This Special Issue will provide an opportunity to cover studies considering animal models, biochemical and/or experimental studies investigating molecular pathways, or reviews exploring molecular and pathogenic mechanisms revealing new insights into the comprehension of the pathophysiological modification associated with the effects of sex and gender on neurological diseases. The issue will contribute to highlight how pathologic processes of neurological and neurodegenerative diseases can be determined or modified by sex dependent issues.

Dr. Paolo Ragonese
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gender and sex differences
  • neurological disorders
  • neurodegeneration
  • neuroprotection
  • Parkinson’s disease
  • stroke
  • multiple sclerosis
  • dementia

Published Papers

There is no accepted submissions to this special issue at this moment.
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