Special Issue "Gene-Diet Interactions in Chronic Diseases"
Deadline for manuscript submissions: closed (30 June 2017).
Interests: nutrigenetics; nutrigenomics; nutrigenomics technologies; genetic toxicology; DNA damage and repair; environmental mutagenesis; environmental carcinogenesis; mechanisms of anticancer drug action; gene–diet interactions—particularly in prostate and colorectal cancer; inflammatory bowel disease and other inflammation-related disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue in Nutrients: Polyphenols for Cancer Treatment or Prevention
Special Issue in Nutrients: Nutrition and Diet in IBD
Special Issue in Nutrients: Nutrigenomics and the Future of Nutrition
Interests: nutritional intervention; systems biology; integrative medicine; gene-diet interactions; personalised nutrition
Three main factors have contributed to the emergence of nutrigenetics: The sequencing of the human, mouse and rat genomes, new understandings of the ways in which macronutrients and micronutrients interact with our genetic makeup, and improved understanding of the mechanisms that underlie chronic inflammation—a central factor in many common diseases, particularly those of a chronic nature.
Among omics tools available, transcriptomics, proteomics and metabolomics have, together, produced molecular biomarkers that allow early dietary intervention which can reverse the onset of diet-related diseases and help regain homeostasis. Microbiomics is also growing as an important tool that studies the genome of a person’s microbiota and enables study of interactions between host’s genome and microbiome plus environmental factors, particularly diet.
Chronic inflammation is understood to be a common underlying mechanism of several chronic diseases, including cardiovascular disease, diabetes, cancer, inflammatory bowel disease, Alzheimer’s disease, asthma, and rheumatoid arthritis. The interplay between genes and diet in the development of chronic disease has been well-documented in recent years, with some studies showing that intervening “upstream” with nutrient intervention can positively impact lower-grade chronic conditions developing into more serious status.
Nutrigenetics has developed at a pace that is often ahead of regulatory guidelines, and outside of practitioner and public understanding. This has not prevented motivated, tech-savvy consumers and patients from accessing genetic and nutritional information, which they see as ‘rightly theirs to know and apply as they wish’. Furthermore, there have been numerous examples that support the usefulness of this tool. Given that those with chronic disease or a predisposition to such are often more motivated than others to learn ways in which to help themselves, personalised nutrition is of particular interest.
This Special Issue, “Gene-Diet Interactions in Chronic Diseases”, will focus on the role of nutrigenetics and the application of personalised nutrition in chronic disease. Experimental papers, up-to-date review articles, and commentaries are all welcome.
Prof. Dr. Lynnette R. Ferguson
Ms. Virginia R. Parslow
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- personalised nutrition
- chronic disease
- gene-diet interaction
- omics technologies