Topical Collection "Emerging Genetic and Genomic Mechanisms in Cell Death and Cell Proliferation "
2. Adjunct Associate Professor of Neurology, Weill Medical College of Cornell University, New York, NY, USA
3. Adjunct Faculty, INDICASAT, Panama
Adjunct Faculty, Texas A & M University Graduate Program, College Station, TX, USA
Houston Methodist Hospital, 6550 Fannin, Smith 8-05，Houston, TX 77030, USA
Interests: DNA damage responses; neurodegenerative diseases; DNA repair defects; RNA binding proteins in DNA repair; genome instability in cell death and proliferation
Special Issues and Collections in MDPI journals
Interests: mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease; the mechanism for RNA-based redox metal binding; the consequences of RNA oxidation on protein synthesis rate and fidelity; the role of redox active metals in mediating prooxidant and antioxidant properties; the signal transduction pathways altered in Alzheimer disease that allow neurons to evade apoptosis; mechanism of phosphorylation control of oxidative damage to neurofilament proteins
Special Issues and Collections in MDPI journals
Interests: targeting inducible epigenetic reprogramming pathways
2: Adjunct Faculty, INDICASAT AIP, Panama
Interests: Cancer; Tumor Immunology and Antibody Drugs; Immunotherapy
Despite an enormous upsurge in our understanding of the cellular and molecular pathways associated with cell death and proliferation, the key molecular determinants to modulate these processes in human diseases is still not revealed completely, hindering the development of effective treatments and prevention avenues for aging, neurodegeneration, and cancer. Growing evidence suggests that neurodegenerative diseases occur less frequently in cancer survivors, and vice versa; however, the mechanistic basis for such an inverse comorbidity relation is unclear. While it is known that cancer and neurodegeneration share many common pathways, the implications/responses for these pathways in proliferating and quiescent cells are obviously different. Recent high-throughput genetic and genomic technologies have enabled genome-scale, multidimensional investigations to facilitate a better understanding of the underlying shared mechanisms and the identification of novel targets. Molecular insights gained through such systems genomics and gene network modeling approaches have provided an opportunity to compare the similarities and differences in cell death and cell proliferation. One area of research, which received great attention in this decade, is altered DNA damage responses (DDR), which play a central role in both neurodegenerative diseases. Persistent genome damage and DDR signaling has diverse cellular implications in both cycling and post-mitotic cells. Notably, several factors linked to genome maintenance are at a crossroads between neurodegeneration and cancer, underscoring their overlapping biology. A number of recent studies have highlighted link between defects in DNA repair pathways in nuclear and mitochondrial genomes, to both inherited and sporadic forms neurodegenerative diseases and cancers. It is important to note that while cells invoke DDR pathways for survival, paradoxical effects of sustained DDR in promoting senescence include inflammatory signaling as well as apoptosis/ferroptosis, all of which are linked to both cell death and abnormal proliferation. Senescence may have opposing implications in neurodegeneration vs. cancer.
This Special Issue will be a Topical Collection of original articles and focused thematic reviews on “Emerging Genetic and Genomic Mechanisms in Cell Death and Cell Proliferation” and is aimed at comprehensively summarizing recent advances in our understanding of genetic and genomic mechanisms during age-associated neurodegeneration and various cancers to stimulate an in-depth debate on what we can learn from the shared pathways in these two fields and challenges for DDR-targeted intervention strategies. We believe that this compendium of scholarly articles and reviews will not only push the current boundary of our understanding but also guide further research in this direction. Articles focusing on either cancer or neurodegeneration or on common pathways are welcome, with a focus on genetic and genomic pathways.
Prof. Muralidhar L. Hegde
Prof. George Perry
Prof. Istvan Boldogh
Prof. Dr. K.S Jagannatha Rao
Prof. Dr. Chong Li
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