Special Issue "Direct Genetic Conversion of Glia Cells to Neurons"
Deadline for manuscript submissions: 31 July 2021.
Interests: aging; stroke; epilepsy; stem cell therapies; rehabilitation; proteomics; genomics
After cerebral ischemia, the ratio between astroglial cells and neurons in the neurovascular unit is disrupted in the perilesional area. Restoring the balance within the neurovascular unit may lead to an improved neurorestoration after focal ischemia. Following cerebral ischemia, proliferating glia become reactive and build up a second barrier to regeneration—known as the glial scar. Although it initially provides protection by confining the damaged area, in the long-term, the glial scar is acting as a physical and chemical barrier to neural regeneration by secretion of inflammatory cytokines, such as TNF-α and interleukin-1β (IL-1β), and accumulation of neurite inhibitory factors, such as chondroitin sulfate proteoglycans and lipocalin-2. Direct astroglial reprogramming to neurons using viral vectors that carry transcription factors, such as Sox2, Ng2 or Ascl1, provides a completely new strategy for neurorestoration after stroke and other traumatic brain injuries. Therefore, in this Special Issue, we invite groups working on genetic conversion of glia cells to share their experience with the scholars of brain injuries in an attempt to find new therapeutic options for neurorestoration after injuries to the brain.
Dr. Aurel Popa-Wagner
Manuscript Submission Information
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- cerebral ischemia
- traumatic brain injury
- genetic conversion