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Special Issue "Direct Genetic Conversion of Glia Cells to Neurons"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Dr. Aurel Popa-Wagner
E-Mail Website
Guest Editor
Griffith University Menzies Health Institute of Queensland Gold Coast Campus and Queensland Eye Institute, Australia and Professor of Experimental Neurology and Biochemistry, University of Medicine and Pharmacy Craiova, Brisbane, QLD 4000, Romania
Interests: aging; stroke; epilepsy; stem cell therapies; rehabilitation; proteomics; genomics

Special Issue Information

Dear Colleagues,

After cerebral ischemia, the ratio between astroglial cells and neurons in the neurovascular unit is disrupted in the perilesional area. Restoring the balance within the neurovascular unit may lead to an improved neurorestoration after focal ischemia. Following cerebral ischemia, proliferating glia become reactive and build up a second barrier to regeneration—known as the glial scar. Although it initially provides protection by confining the damaged area, in the long-term, the glial scar is acting as a physical and chemical barrier to neural regeneration by secretion of inflammatory cytokines, such as TNF-α and interleukin-1β (IL-1β), and accumulation of neurite inhibitory factors, such as chondroitin sulfate proteoglycans and lipocalin-2. Direct astroglial reprogramming to neurons using viral vectors that carry transcription factors, such as Sox2, Ng2 or Ascl1, provides a completely new strategy for neurorestoration after stroke and other traumatic brain injuries. Therefore, in this Special Issue, we invite groups working on genetic conversion of glia cells to share their experience with the scholars of brain injuries in an attempt to find new therapeutic options for neurorestoration after injuries to the brain.

Dr. Aurel Popa-Wagner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cerebral ischemia
  • traumatic brain injury
  • neurorestoration
  • genetic conversion
  • Sox2
  • Ng2
  • Ascl1

Published Papers

This special issue is now open for submission.
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