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Special Issue "New Advance in Compositional Genome Evolution"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editor

Dr. Radka Symonova
E-Mail Website
Guest Editor
Department of Bioinformatics, Technical University of Munich, 85354 Freising, Germany
Interests: genome evolution; GC-biology; fish chromosomes; rDNA genes

Special Issue Information

Dear Colleagues,

Nucleotide composition, i.e., not only the primary DNA sequence but also the proportion of AT versus GC, is a crucial factor driving important genomic features like gene density, DNA methylation, DNA mutations, DNA replication timing, chromatin structure, proportion and types of transposons, nucleosome formation potential, and many more. However, despite the still increasing number of sequenced genomes, it is still unclear why mammalian and avian genomes are AT/GC heterogeneous, whereas genomes of lower vertebrates are AT/GC homogenous.

In this Special Issue, we aim to integrate the latest results from prokaryotes and eukaryotes, plants and animals, unicellular and multicellular organisms, and above all vertebrates to assess the currently relevant viewpoints of the compositional genome evolution. Namely, we aim to analyse GC-related structural as well as functional traits regarding neutral evolutionary processes and potential roles of selection in genomes and their transposons.

Dr. Radka Symonova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • AT/GC evolution in prokaryotes
  • AT/GC evolution in eukaryotes
  • AT/GC evolution of eukaryotic transposons (active, inactive, DNA transposons, retrotransposons)
  • Role of selection in GC biology
  • Levels of gene expression and GC content

Published Papers

There is no accepted submissions to this special issue at this moment.
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