Special Issue "Glucocorticoid Signaling Pathway: From Bench to Bedside"
Deadline for manuscript submissions: 31 August 2021.
Interests: endocrinology; molecular endocrinology; pediatrics; pediatric endocrinology; genetics; epigenetics; stress; stress biology and medicine; human physiology
Special Issues and Collections in MDPI journals
Glucocorticoids are steroid hormones produced by the adrenal cortex and secreted into the systemic circulation in a circadian or stress-related fashion. Their secretion is under the complex control of the hypothalamic-pituitary-adrenal (HPA) axis, a major component of the stress system. Glucocorticoids play fundamental roles in the maintenance of resting and stress-related homeostasis. They regulate a broad spectrum of physiologic functions, including those of the central nervous, cardiovascular, metabolic, and immune systems. All pleiotropic actions of glucocorticoids are mediated by the ubiquitously expressed glucocorticoid receptor (hGR), which functions as a ligand-activated transcription factor influencing the transcription of approximately 20% of the human genome in a positive or negative fashion. In addition to their genomic actions, glucocorticoids may exert their effects within seconds or minutes through non-genomic actions, possibly mediated by membrane-bound hGRs.
Furthermore, glucocorticoid receptors are located within mitochondria where they may regulate cellular energy production. Either through genomic or non-genomic mechanisms, tissue glucocorticoid sensitivity is influenced by several factors, such as NR3C1 gene polymorphisms or mutations, presence of multiple hGR protein isoforms, an ever increasing number of interacting partners, including many proteins, as well as noncoding RNA molecules (microRNAs, long non-coding RNAs, etc.). Glucocorticoids have many epigenetic actions that can be stimulatory or inhibitory. These are exerted especially strongly during critical periods of life, such as the prenatal period, the first 5 years of life, and the pubertal and young adult ages. In this special issue, we aim to present the diverse and complex actions of glucocorticoids through their intracellular signaling pathways from bench to bedside.
Prof. Dr. George Panagiotis Chrousos
Dr. Nicolas C. Nicolaides
Manuscript Submission Information
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- glucocorticoid receptor
- glucocorticoid signaling
- NR3C1 gene mutations
- NR3C1 gene polymorphisms
- synthetic glucocorticoids