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Special Issue "Glucocorticoid Signaling Pathway: From Bench to Bedside"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Prof. Dr. George P. Chrousos
E-Mail Website
Guest Editor
National and Kapodistrian University of Athens, Athens, Greece
Interests: endocrinology; molecular endocrinology; pediatrics; pediatric endocrinology; genetics; epigenetics; stress; stress biology and medicine; human physiology
Special Issues and Collections in MDPI journals
Dr. Nicolas C. Nicolaides
E-Mail Website
Guest Editor
National and Kapodistrian University of Athens, Athens, Greece
Interests: endocrinology; molecular endocrinology; pediatrics; pediatric endocrinology; genetics; epigenetics; stress; stress biology and medicine; human physiology

Special Issue Information

Dear Colleagues,

Glucocorticoids are steroid hormones produced by the adrenal cortex and secreted into the systemic circulation in a circadian or stress-related fashion. Their secretion is under the complex control of the hypothalamic-pituitary-adrenal (HPA) axis, a major component of the stress system. Glucocorticoids play fundamental roles in the maintenance of resting and stress-related homeostasis. They regulate a broad spectrum of physiologic functions, including those of the central nervous, cardiovascular, metabolic, and immune systems. All pleiotropic actions of glucocorticoids are mediated by the ubiquitously expressed glucocorticoid receptor (hGR), which functions as a ligand-activated transcription factor influencing the transcription of approximately 20% of the human genome in a positive or negative fashion. In addition to their genomic actions, glucocorticoids may exert their effects within seconds or minutes through non-genomic actions, possibly mediated by membrane-bound hGRs.

Furthermore, glucocorticoid receptors are located within mitochondria where they may regulate cellular energy production. Either through genomic or non-genomic mechanisms, tissue glucocorticoid sensitivity is influenced by several factors, such as NR3C1 gene polymorphisms or mutations, presence of multiple hGR protein isoforms, an ever increasing number of interacting partners, including many proteins, as well as noncoding RNA molecules (microRNAs, long non-coding RNAs, etc.). Glucocorticoids have many epigenetic actions that can be stimulatory or inhibitory.  These are exerted especially strongly during critical periods of life, such as the prenatal period, the first 5 years of life, and the pubertal and young adult ages.   In this special issue, we aim to present the diverse and complex actions of glucocorticoids through their intracellular signaling pathways from bench to bedside.

Prof. Dr. George Panagiotis Chrousos
Dr. Nicolas C. Nicolaides
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glucocorticoids
  • glucocorticoid receptor
  • glucocorticoid signaling
  • NR3C1 gene mutations
  • NR3C1 gene polymorphisms
  • synthetic glucocorticoids

Published Papers (1 paper)

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Research

Open AccessArticle
Rapid Screening of Glucocorticoid Receptor (GR) Effectors Using Cortisol-Detecting Sensor Cells
Int. J. Mol. Sci. 2021, 22(9), 4747; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094747 - 29 Apr 2021
Viewed by 249
Abstract
Cortisol, a stress hormone, plays key roles in mediating stress and anti-inflammatory responses. As abnormal cortisol levels can induce various adverse effects, screening cortisol and cortisol analogues is important for monitoring stress levels and for identifying drug candidates. A novel cell-based sensing system [...] Read more.
Cortisol, a stress hormone, plays key roles in mediating stress and anti-inflammatory responses. As abnormal cortisol levels can induce various adverse effects, screening cortisol and cortisol analogues is important for monitoring stress levels and for identifying drug candidates. A novel cell-based sensing system was adopted for rapid screening of cortisol and its functional analogues under complex cellular regulation. We used glucocorticoid receptor (GR) fused to a split intein which reconstituted with the counterpart to trigger conditional protein splicing (CPS) in the presence of targets. CPS generates functional signal peptides which promptly translocate the fluorescent cargo. The sensor cells exhibited exceptional performance in discriminating between the functional and structural analogues of cortisol with improved sensitivity. Essential oil extracts with stress relief activity were screened using the sensor cells to identify GR effectors. The sensor cells responded to peppermint oil, and L-limonene and L-menthol were identified as potential GR effectors from the major components of peppermint oil. Further analysis indicated L-limonene as a selective GR agonist (SEGRA) which is a potential anti-inflammatory agent as it attenuates proinflammatory responses without causing notable adverse effects of GR agonists. Full article
(This article belongs to the Special Issue Glucocorticoid Signaling Pathway: From Bench to Bedside)
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