Special Issue "Prevention and/or Repair of Glycation in Mammalian and Invertebrate"
Deadline for manuscript submissions: 31 March 2021.
Interests: Glycation; Park7; Enzymology; toxicology; analytical chemistry; oxidative stress; Xenobiotic; metabolism
The purpose of this Special Issue is to map the glycation prevent and/or repair system in mammalians and invertebrates. Glycation is a non-enzymatic reaction discovered by Louis Camille Maillard that occurs between reducing sugars or dicarbonyls (mainly glyoxal and methylglyoxal) and thiol or amino groups of proteins, nucleic acids, and aminolipids. Protein glycation begins with a condensation reaction between carbonyl groups and amino acids, after which a series of dehydrations, oxidations, and rearrangements leads to a myriad of products, including Schiff bases, Amadori products, advanced glycation end-products (AGEs), and protein crosslinks. Glycation results in protein inactivation and aggregation, mutations, and tumorigenesis and is involved in aging, atherosclerosis, hypertension, and neurovegetative, renal, autoimmune, and post-diabetic diseases. Thus, inhibiting any step of glycation can help in the prevention of these diseases. There are several systems for limiting glycation, among them enzymatic activities (glyoxalases, Park7/DJ-1) but also small molecules acting as scavengers of glycating agents. The Special Issue on “Prevention and/or Repair of Glycation in Mammalians and Invertebrates” will include historic reviews of the molecular science behind glycation and original data that focus on defining the following:
- Detoxification of glyoxals by enzymes;
- Scavengers of glycating agents;
- Metabolic syndrome and glycation;
- The enzymes involved in the protection against glycation, i.e., the new targets for anticancer drug development.
Dr. Julien Dairou
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Advanced glycation end products (AGEs)
- Maillard reaction
- Protein glycation
- DNA and protein repair