Special Issue "Glyoxalase System"
Deadline for manuscript submissions: closed (30 November 2016).
Interests: endothelial cell biology; obesity; insulin resistance; vascular complications; endothelial function
Special Issues and Collections in MDPI journals
The glyoxalase system, as discovered in 1913, is the main system involved in the detoxification of methylglyoxal. It involves the rate-limiting enzyme glyoxalase 1 (GLO1) and the GLO2 enzyme. GLO1 catalyzes the conversion of the MGO-GSH hemithioacetal to the thioester S-d-lactoylglutathione. The mechanisms regulating GLO1 activity is complex, comprising both regulation of gene expression and post-translational modifications of the enzyme. Increased levels of methylglyoxal and/or dysfunction of the glyoxalase system have frequently been found in relation to ageing and age-related diseases.
Methylglyoxal and the glyoxalase system have been thoroughly examined by numerous research groups for many decades. Several important contributions have been made in this field. In this Special Issue, progress made in all aspects of methylglyoxal and the glyoxalase system will be included. We ask the experts in the field to contribute their latest research, perspective, or reviews on this fascinating and rapidly progressing topic. Our aim is to provide a comprehensive update of the biochemistry of methylglyoxal and GLO-1, their role in age-related diseases and therapeutic options.
Prof. Dr. Casper G. Schalkwijk
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Age-related disease
- Translational medicine
- Molecular mechanism
- Drug discovery