Special Issue "Glyoxalase System in Health and Disease 2017"
Deadline for manuscript submissions: closed (31 December 2017).
Interests: endothelial cell biology; obesity; insulin resistance; vascular complications; endothelial function
Special Issues and Collections in MDPI journals
Endogenous methylglyoxal is formed from metabolic intermediates of carbohydrates and fatty acids. Methylglyoxal is the major precursor in the formation of advanced glycation endproducts. The glyoxalase system is the main system involved in the detoxification of methylglyoxal. Despite the detoxification of methylglyoxal, some diseases still lead to elevated levels of cellular methylglyoxal. Increased levels of methylglyoxal and/or dysfunction of the glyoxalase system have frequently been found in relation to ageing and age-related diseases, such as vascular diseases and diabetes. In this Special Issue, I invite investigators to contribute original research articles or review articles that will stimulate the continuing efforts to understand the role of the glyoxalase system, as well as the mechanism underlying methylglyoxal-induced cell/organ under normal and diseased conditions. Our aim is to provide a comprehensive update of the glyoxalase system and methylglyoxal in age-related diseases and therapeutic options.
Prof. Dr. Casper G. Schalkwijk
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Age-related disease
- Translational medicine
- Molecular mechanism
- Drug discovery