Dear Colleagues, 

Heterotrimeric G-proteins function as molecular switches during signaling to regulate diverse physiological functions in eukaryotes. Predominantly, G proteins, comprising of α-, β-and γ-subunits, transduce a wide variety of extracellular stimuli to generate a plethora of cellular responses.  In a the resting state, GDP-bound α-subunit is complexed with the β- and γ-subunits. The exchange of GDP bound on the α-subunit with GTP leads to the dissociation of α subunit from βγ dimer resulting in two functional subunits (α and βγ), which modulate various cellular pathways by binding with effectors. The G-protein deactivation occurs, when G-proteins hydrolyze GTP by the action of GAPs, like RGS, thereby accelerating the termination of signaling. In animals, the regulatory cycle of G-proteins depends on activation/inactivation through GPCR; whereas in plants the conventional G-protein regulation by GPCR is still questionable. With the advancements of biological and computational techniques, myriad progress has been made in understanding the mechanisms by which G-proteins turn on or off by signal-receptor interactions as well as regulate their downstream targets in plants. 

This Special Issue of IJMS will provide a comprehensive overview of this exciting and emerging field of G-proteins for a better understanding of their critical role in mediating signal transduction in plant cells. The current Special Issue is open to submission of previously unpublished experimental, theoretical, prospective, and review papers. 

Dr. Swarup Roy Choudhury
Guest Editor

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• Biotic and abiotic stress
• Cell signaling
• Effectors
• Endocytosis
• GTPase-accelerating proteins
• Growth and Development
• Heterotrimeric G proteins
• Hormone
• Interaction network
• Phosphorylation
• Receptor-like kinases