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Special Issue "Gut-Brain Axis: New Pathophysiological Scenarios and Therapeutic Strategies"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editors

Dr. Roberto R. Russo
E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples Federico II, Naples, Italy
Interests: pain; inflammation; neuropathic pain; cannabinoid system; TRPM8; microbiota; gut - brain axis; neurodegenerative diseases-microbiota
Dr. Claudia Cristiano
E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples Federico II, Naples, Italy
Interests: behaviour; autism spectrum disorder; pain; inflammation; lipids; cannabinoid system; microbiota; gut - brain axis; neurodegenerative diseases

Special Issue Information

Dear Colleagues,

Currently, the microbiota–gut–brain axis is emerging as a special scientific area of interest and a possible new target for different disorders. Modification in the gut microbiota composition appears to influence behaviour, cognitive processes, and the pain systems by modulating endocrine, immune, metabolic, and neuronal pathways. A better understanding of the mechanism by which the gut–brain axis is involved in chronic diseases may open new therapeutic strategies.

The aim of this Special Issue is focused on understanding how an alteration of gut functionality, such as dysbiosis, is involved in different diseases (i.e., neurological and neurodegenerative diseases, chronic pain, obesity, and inflammatory bowel diseases), looking at the identification of specific pathways, risk factors, or conditions to develop better and safer therapies. We invite all interested researchers to submit review articles or original papers related to the topic of this Special Issue, guided by the keywords below.

Dr. Roberto R. Russo
Dr. Claudia Cristiano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic pain
  • microbiota composition
  • gut–brain axis
  • chronic diseases
  • neurological disease
  • animal models
  • neurodegenerative disease
  • therapeutics
  • molecular pathway

Published Papers (1 paper)

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Research

Article
Supplementation with Lactiplantibacillus plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats
Int. J. Mol. Sci. 2021, 22(20), 11171; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011171 - 16 Oct 2021
Viewed by 262
Abstract
Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of Lactiplantibacillus (L.) plantarum [...] Read more.
Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of Lactiplantibacillus (L.) plantarum IMC 510 in a rat model of diet-induced obesity, specifically in the cafeteria (CAF) diet. This diet provides a strong motivation to voluntary overeat, due to the palatability and variety of selected energy-dense foods. The oral administration for 84 days of this probiotic strain, added to the CAF diet, decreased food intake and body weight gain. Accordingly, it ameliorated body mass index, liver and white adipose tissue weight, hepatic lipid accumulation, adipocyte size, serum parameters, including glycemia and low-density lipoprotein levels, in CAF fed rats, potentially through leptin control. In this scenario, L. plantarum IMC 510 showed also beneficial effects on GM, limiting the microbial imbalance established by long exposure to CAF diet and preserving the proportion of different bacterial taxa. Further research is necessary to better elucidate the relationship between GM and overweight and then the mechanism of action by which L. plantarum IMC 510 modifies weight. However, these promising results prompt a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in obesity prevention and management. Full article
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