Special Issue "Heme- and Hemoglobin Stress in Human Diseases"
Deadline for manuscript submissions: 30 April 2021.
Interests: heme- and hemoglobin-mediated vascular damage; vascular and valvular mineralization
The aim of this Special Issue is to promote research concerning the involvement of heme and heme proteins in the pathogenesis of various diseases as well as preventive and therapeutic strategies to minimize damage through associated pathways.
Heme is the principal iron complex in the human body with vital physiological functions and strictly regulated metabolism, responsible for oxygen and electron transport among many other roles. This diverse capability is achieved through the numerous combinations that result from associations of heme with various protein chains.
Under pathological conditions, heme can escape from its safe and functional sanctuaries and interact with cellular domains and tissue constituents, allowing pathophysiologic remodeling. Given the hydrophobic nature of heme, it is no surprise that it easily crosses cell membranes and can synergistically enhance cellular oxidant damage. In addition, through binding, it alters the functions of proteins, lipids, and nucleic acids, affecting signaling pathways, cell differentiation, cell–cell interactions, contractility, etc.
Heme moieties of some heme proteins may react with peroxides, leading to the formation of protein radicals and thereby altering their structures, actions, and functions. Hydrogen sulfide, nitrogen monoxide, and carbon monoxide were shown to have impact on such physiology and pathophysiology.
Of all the sites in the body, the vasculature may be at the greatest risk of harm exhibited by heme and heme proteins, including hemoglobin. Substantial evidence is accumulating regarding the existence of heme and hemoglobin stress as well as adaptation against its damaging effects.
Prof. Dr. József Balla
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- heme proteins
- free radicals
- hemoglobin oxidation
- hydrogen sulfide
- nitrogen monoxide
- carbon monoxide
- heme oxygenase
- biliverdin reductase
- iron metabolism