Special Issue "Molecular Biology of Histamine Systems"
Deadline for manuscript submissions: 31 December 2021.
Interests: ER stress; oxidative stress; inflammation; senescence; autophagy; proteinopathies; metallopathies; channelopathies; chronic; neuroglia; vascular
Histamine is arguably the most pleiotropic transmitter in the human body. Despite over a century of study since the first seminal work of Sr Henry Dale, who first identified an action for histamine on living tissue, and with significant advances in histamine pharmacology and drug development, with successful drug targeting three of the four histamine receptors, H1-4R, we are still lacking in a full understanding of the molecular biology of the histamine system. Histamine is synthesized from the amino acid histidine via the enzyme, histadine decarboxylase (HDC). The histamine receptors are classic G-protein coupled receptors. Major pharmacological heterogeneity between and within species has hindered the clinical development of H3 and H4R-targeted drugs. The pharmacological heterogeneity displayed by the histamine receptors are thought in part to be a result of alternative splicing which generates a number of possible splice variants, some of which have been shown to be functional and others which appear to be non-functional in terms of ligand binding and signal transduction. mRNA encoding the different isoforms has been shown to be distributed throughout the central nervous system in a region specific manner, but their relevance is yet to be established. Genetic polymorphisms have also been identified within the human receptor and HDC genes, some have been linked to disease. Despite the importance of histamine, transcriptional regulation of histamine receptor and HDC gene expression in mammals is still poorly understood. Furthermore, there are significant deficits in our knowledge regarding native histamine signalling pathways. This themed volume will endeavour to extend our understanding of these important issues.
Prof. Dr. Paul Chazot
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Molecular biology
- Histamine signalling
- Gene regulation
- Molecular structure