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Special Issue "Hormone Signaling in Human Health and Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Antonella Muscella
E-Mail Website
Guest Editor
Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Prov.le Lecce-Monteroni, Centro Ecotekne, 73100 Lecce, Italy
Interests: signal transduction; hormones; apoptosis; autophagy; metabolism

Special Issue Information

Dear Colleagues,

Cell signaling is part of any communication process that regulates the basic activities of cells and coordinates all cellular actions. The ability of cells to perceive and respond correctly to their microenvironment underlies the development, repair of tissues, immunity, and homeostasis of normal tissues. Errors in signaling interactions and cellular information processing are responsible for three large classes of non-infectious diseases—cancers, neurodegenerative disorders, and metabolic syndromes (such as type 2 diabetes and atherosclerosis). These diseases are remarkably complex and difficult to treat, primarily because when the cellular signaling pathways responsible for homeostasis and health of the body become dysregulated, they generate similarly stable disease states.

Health- and disease-related conditions are dynamic and positively and negatively regulated by different feedback loops acting between pathways. Understanding cell signaling, especially for the hormone signaling, and describing regulatory networks in healthy and diseased states will show which molecular components might be prime targets for drug interventions to better deal with these diseases. This is accomplished by studying models that explain in mechanistic, molecular detail how a detailed part of the cellular signaling pathway acts properly in health and wrong in disease.

Prof. Dr. Antonella Muscella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hormone
  • cell receptor
  • endocrine signaling
  • cancer
  • insulin
  • oestrogen
  • testosterone
  • angiotensin
  • gonadotropin
  • thyroid hormone

Published Papers (1 paper)

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Review

Review
The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review
Int. J. Mol. Sci. 2021, 22(16), 8814; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168814 - 16 Aug 2021
Viewed by 419
Abstract
(1) Background: One mechanism through which physical activity (PA) provides benefits is by triggering activity at a molecular level, where neurotrophins (NTs) are known to play an important role. However, the expression of the circulating levels of neurotrophic factors, brain-derived neurotrophic factor (BDNF) [...] Read more.
(1) Background: One mechanism through which physical activity (PA) provides benefits is by triggering activity at a molecular level, where neurotrophins (NTs) are known to play an important role. However, the expression of the circulating levels of neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4/5), in response to exercise, is not fully understood. Therefore, the aim was to provide an updated overview on the neurotrophin (NT) variation levels of BDNF and NT-4/5 as a consequence of a long-term aerobic exercise intervention, and to understand and describe whether the upregulation of circulating NT levels is a result of neurotrophic factors produced and released from the brain, and/or from neurotrophic secreting peripheral organs. (2) Methods: The articles were collected from PubMed, SPORTDiscus, Web of Science, MEDLINE, and Embase. Data were analyzed through a narrative synthesis. (3) Results: 30 articles studied humans who performed training protocols that ranged from 4 to 48 weeks; 22 articles studied rodents with an intervention period that ranged from 4 to 64 weeks. (4) Conclusions: There is no unanimity between the upregulation of BDNF in humans; conversely, concerning both BDNF and NT-4/5 in animal models, the results are heterogeneous. Whilst BDNF upregulation appears to be in relative agreement, NT-4/5 seems to display contradictory and inconsistent conclusions. Full article
(This article belongs to the Special Issue Hormone Signaling in Human Health and Diseases)
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