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Special Issue "Molecular Mechanisms on Huntington's Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. KyoungJoo Cho
Guest Editor
Department of Life Science, Kyonggi University, Suwon 16227, South Korea
Interests: neurodegenerative disease; Huntington's disease; autophagy; age onset; neuronal disease; ROS

Special Issue Information

Dear Colleagues,

Huntington’s disease (HD) is caused by mutant huntingtin (mHTT) protein that contains abnormally extended polyglutamine repeats. The pathological mHTT has been investigated the mechanisms in each brain region and also ameliorated the toxicity in the brain. Many factors have been implicated in HD including alterations in calcium handling, neurotrophic factor signaling, vesicle transport, ER maintenance, autophagy, and neuroinflammation that is little known in contrast to other neurodegenerative diseases. In HD, the striatum is most affected, which leads to initiate and control movements of the body, limbs, and eyes. Preferential striatal degeneration is a well-known character. Understanding the mechanism of selective neuronal loss is highly important for developing effective treatment. Posttranslational modifications in mHTT have considerably been devoted to multiple sites in the HTT region. Targeting DNA and RNA to modulate protein expression are progressing for molecular therapies targeting HTT expression based on understanding and recovering molecular mechanism.

This special issue focuses on the recent advances on the molecular mechanisms of HD. We warmly welcome submissions of original manuscripts and reviews.

Dr. KyoungJoo Cho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mutant Huntingtin
  • autophagy
  • aggregates
  • neuroinflammation
  • selectivity
  • molecular therapy
  • UPS
  • E3 ligase

Published Papers

This special issue is now open for submission.
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