Special Issue "Molecular Mechanisms on Huntington's Disease"
Deadline for manuscript submissions: 31 August 2021.
Interests: neurodegenerative disease; Huntington's disease; autophagy; age onset; neuronal disease; ROS
Huntington’s disease (HD) is caused by mutant huntingtin (mHTT) protein that contains abnormally extended polyglutamine repeats. The pathological mHTT has been investigated the mechanisms in each brain region and also ameliorated the toxicity in the brain. Many factors have been implicated in HD including alterations in calcium handling, neurotrophic factor signaling, vesicle transport, ER maintenance, autophagy, and neuroinflammation that is little known in contrast to other neurodegenerative diseases. In HD, the striatum is most affected, which leads to initiate and control movements of the body, limbs, and eyes. Preferential striatal degeneration is a well-known character. Understanding the mechanism of selective neuronal loss is highly important for developing effective treatment. Posttranslational modifications in mHTT have considerably been devoted to multiple sites in the HTT region. Targeting DNA and RNA to modulate protein expression are progressing for molecular therapies targeting HTT expression based on understanding and recovering molecular mechanism.
This special issue focuses on the recent advances on the molecular mechanisms of HD. We warmly welcome submissions of original manuscripts and reviews.
Dr. KyoungJoo Cho
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- mutant Huntingtin
- molecular therapy
- E3 ligase