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Hypertension and Cardiovascular Diseases: From Etiopathogenesis to Potential Therapeutic Targets 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3121

Special Issue Editors

Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia
Interests: coronary artery disease; myocardial infarction; cardioprotective interventions; ischemic conditioning; experimental hypertension; diabetes mellitus; hyperlipidaemia; natural antioxidants; flavonoids; extracellular vesicles; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals
1. Department of Experimental Hypertension, Institute of Normal and Pathological Physiology, Centre of Experimental Medicine of Slovak Academy of Sciences, Bratislava, Slovakia
2. Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Interests: hypertension; diabetes mellitus; hypercholesterolemia; vascular physiology; ion channels and ion homeostatis; endothelium; endothelium-derived factors; cyclooxygenase pathway; sympathetic nervous system; ontogenetic development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs), including coronary heart disease and arterial hypertension, are the top cause of death worldwide, and arterial hypertension per se remains the major preventable cause of CVDs. The prevalence of hypertension increases with age, but prehypertension is common among the young population. Risk factors of CVDs consist of non-modifiable factors (genetic composition, age, sex, race) and modifiable factors such as smoking, unhealthy diet, physical inactivity, and stress. CVDs are often associated with dyslipidemia, type two diabetes mellitus, hypercholesterolemia, and obesity. Hypertension, heart disease, and diabetes mellitus are also medical conditions negatively affecting the prognosis of patients infected with SARS-CoV-2.

The pathophysiology of CVDs involves multiple factors, amongst them alterations in the sympathetic nervous system, renin-angiotensin-aldosterone system, endothelial dysfunction, inflammation, and oxidative stress. In addition, alterations in intracellular and extracellular signaling pathways may be involved. Specifically, various nuclear factors and receptors involved in the regulation of antioxidant defense, nitric oxide production, inflammation, energy, and/or iron metabolism provide new targets for the prevention and treatment of CVDs and comorbid diseases.

This Special Issue will focus on novel mechanisms in the etiopathogenesis of arterial hypertension and coronary heart disease, prevention, and potential therapeutic targets of CVDs. Original research articles, reviews, short communications, and epidemiological studies are welcome.

This Special Issue is jointly organized between /IJMS/ and /Biomedicines/. In accordance with the Aims and Scope of these journals, articles covering molecular studies can be submitted to /IJMS/, whereas articles presenting more clinical content can be submitted to /Biomedicines/.

Dr. Iveta Bernatova
Dr. Monika Bartekova
Dr. Silvia Liskova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arterial hypertension
  • coronary heart disease
  • COVID-19
  • endothelium
  • inflammation
  • oxidative stress
  • gasotransmitters
  • receptors and ion channels
  • transcriptional factors
  • non-coding RNA
  • gene expression
  • nuclear factors and receptors
  • cardioprotection
  • prevention and treatment: natural polyphenols, antioxidants, gut microbiota

Published Papers (1 paper)

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Research

28 pages, 1824 KiB  
Article
Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients
by Dmitry Oshchepkov, Irina Chadaeva, Rimma Kozhemyakina, Karina Zolotareva, Bato Khandaev, Ekaterina Sharypova, Petr Ponomarenko, Anton Bogomolov, Natalya V. Klimova, Svetlana Shikhevich, Olga Redina, Nataliya G. Kolosova, Maria Nazarenko, Nikolay A. Kolchanov, Arcady Markel and Mikhail Ponomarenko
Int. J. Mol. Sci. 2022, 23(5), 2835; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23052835 - 04 Mar 2022
Cited by 9 | Viewed by 2622
Abstract
Although half of hypertensive patients have hypertensive parents, known hypertension-related human loci identified by genome-wide analysis explain only 3% of hypertension heredity. Therefore, mainstream transcriptome profiling of hypertensive subjects addresses differentially expressed genes (DEGs) specific to gender, age, and comorbidities in accordance with [...] Read more.
Although half of hypertensive patients have hypertensive parents, known hypertension-related human loci identified by genome-wide analysis explain only 3% of hypertension heredity. Therefore, mainstream transcriptome profiling of hypertensive subjects addresses differentially expressed genes (DEGs) specific to gender, age, and comorbidities in accordance with predictive preventive personalized participatory medicine treating patients according to their symptoms, individual lifestyle, and genetic background. Within this mainstream paradigm, here, we determined whether, among the known hypertension-related DEGs that we could find, there is any genome-wide hypertension theranostic molecular marker applicable to everyone, everywhere, anytime. Therefore, we sequenced the hippocampal transcriptome of tame and aggressive rats, corresponding to low and high stress reactivity, an increase of which raises hypertensive risk; we identified stress-reactivity-related rat DEGs and compared them with their known homologous hypertension-related animal DEGs. This yielded significant correlations between stress reactivity-related and hypertension-related fold changes (log2 values) of these DEG homologs. We found principal components, PC1 and PC2, corresponding to a half-difference and half-sum of these log2 values. Using the DEGs of hypertensive versus normotensive patients (as the control), we verified the correlations and principal components. This analysis highlighted downregulation of β-protocadherins and hemoglobin as whole-genome hypertension theranostic molecular markers associated with a wide vascular inner diameter and low blood viscosity, respectively. Full article
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