Special Issue "Hypothalamic Regulation of Obesity"
Deadline for manuscript submissions: closed (30 April 2021).
Interests: obesity; hypothalamus; metabolic syndrome; vascular function; endocannabinoids
Special Issues and Collections in MDPI journals
The obesity epidemic represents a major socioeconomic problem that urgently requires a better understanding of the mechanisms mediating the imbalance between food intake and energy expenditure and of obesity-related metabolic and cardiovascular complications. Gaining insight into the cellular basis of obesity could lay the foundations for the development of new therapeutic strategies.
In the last few decades, it has been strongly demonstrated that the hypothalamus is the critical brain region regulating energy homeostasis. The hypothalamus contains hormonal- and nutrient-sensing nuclei that organize central and peripheral responses for maintaining normal body weight, food intake, energy expenditure and nutrient partitioning. Within the hypothalamus, numerous specialized neuronal populations are connected to each other and also to various extrahypothalamic brain regions to coordinate energy homeostasis. Evidence also suggests the participation of non-neuronal populations, such as astrocytes, or even the interesting interplay between astrocytes and hypothalamic neurons, whose disruption leads to insulin resistance and obesity.
This Special Issue will report on the most recent insights into the hypothalamic neuronal and non-neuronal pathways involved in obesity development. Novel findings related to key systems, such as endocannabinoid and melanocortin-related pathways, in the hypothalamus will be discussed. In addition, the emerging contribution of the cross-talk between the hypothalamus and peripheral tissues, such as gut and adipose tissue, in obesity will be a promising topic to deal with. Therefore, here we will present an overview of the most recent mechanisms underlying the hypothalamic regulation of obesity and the impact of these investigations in the prevention and treatment of human obesity.
Dr. Rosalía Rodríguez-Rodríguez
Manuscript Submission Information
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- food intake
- energy expenditure
- energy homeostasis
- insulin resistance
- glucose homeostasis
- lipid metabolism
- adipose tissue
- gut-brain axis