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Special Issue "Insulin Signaling and Fat Homeostasis in Metabolic and Neurodegenerative Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Prof. Dr. Maria Gisella Cavallo
E-Mail Website
Guest Editor
Sapienza Univ, Policlin Umberto I, Viale Regina Elena 324, I-00161 Rome, Italy
Interests: metabolic disease; obesity; adipose tissue; diabetes; NAFLD
Prof. Dr. Marco Giorgio Baroni
E-Mail Website
Guest Editor
Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, Italy
Interests: diabetes; atherosclerosis; cardiovascular disease; genetics; obesity
Prof. Dr. Eugenio Barone
E-Mail Website
Guest Editor
Department of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: insulin signaling; insulin resistance; aging; Alzheimer’s disease; Down syndrome; neurodegeneration; mitochondrial bioenergetics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Alterations of insulin signaling leading to reduced insulin sensitivity are increasingly recognized as key elements in a variety of chronic noncommunicable diseases, including diabetes, metabolic syndrome, MAFLD, and cardiovascular and neurodegenerative diseases.

In recent years, new molecular mechanisms/pathways have emerged, which increase our comprehension of how these diseases develop and progress. These advances in the field of chronic noncommunicable diseases have identified new potential mechanisms implicated in the development of these disorders (i.e., signaling molecules, adipokines, genetic, epigenetic reprogramming, new biomarkers) that could lead to the development of new approaches and pharmacological targets aimed at preventing and/or overturning these disorders and the associated complications.

The aim of this Special Issue is to bring together research papers and review articles that will drive the focus on the present knowledge in the context of chronic noncommunicable diseases, with a special focus on diabetes, metabolic syndrome, MAFLD, and cardiovascular and neurodegenerative diseases, with the purpose of better understanding the pathways involved in these alterations, and ultimately shedding light on newer approaches to prevent or reverse these diseases.

Prof. Dr. Maria Gisella Cavallo
Prof. Dr. Marco Giorgio Baroni
Prof. Dr. Eugenio Barone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Insulin
  • Diabetes
  • Neurodegeneration
  • Obesity
  • Cardiovascular alterations
  • Oxidative stress
  • Inflammation
  • Fat homeostasis
  • Dementia
  • Brain metabolism

Published Papers

This special issue is now open for submission.
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