Special Issue "The Role of Interleukin in Health and Diseases"
Deadline for manuscript submissions: 30 November 2021.
Interests: biodefence; cancer immunity; cytokine; diversity of myeloid cell; diversity of cell signaling; immunology; inflammatory disease; innate immunity; myeloid-derived suppressor cell (MDSC); neutrophils
Interleukin is a general term for physiologically active substances produced by various cells including immune cells. Most interleukins are glycoproteins, the molecular weight of which is around 10,000 to 100,000. One interleukin molecule exerts various physiological activities. Interestingly, a cascade network of interleukin production exists with its inhibitor production. Therefore, interleukins are essential for cells to interact with each other, and are also called "words" used by cells. Words (interleukins) harmonize the innate immune system and the acquired immune system, and then defend from infection.
Recently, autoimmune diseases, cancer (carcinogenesis/angiogenesis/metastasis), neurodegenerative diseases, arteriosclerotic diseases, and COVID-19 cytokine storm have been added to the definition of words classified as inflammatory cytokines. To read these words, studies on interleukin production mechanisms, gene regulation mechanisms, receptor systems, and signal transduction have been vigorously conducted, and the meaning of words has become clearer. Furthermore, words are released not only from immune cells but also from various tissues such as fat, muscle, and nerve. By reading words from various tissues, it is possible to understand the homeostatic breakdown in a body.
At present, we are able to read some of the words and to assume the behavior of cells. By overwriting cell words with anti-TNFα antibody, anti-IL-6 receptor antibody, IL-1ra, and JAK inhibitor, it has become possible to suppress the behavior of inflammatory cells. However, we have not yet fully understood the complex conversations created by cell interactions. In the future, understanding the network structure of words as conversation will open a new avenue to develop therapies for various diseases.
The Special Issue "Interleukin" covers the actions of interleukins in various diseases, production mechanisms, gene regulation mechanisms, receptor systems, signal transduction, and systems biological approaches. We hope that this Special Issue will provide a platform for enhancing research on interleukins.
Dr. Yuji Takeda
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- interleukins in physiology
- receptor system
- signal transduction
- gene regulation
- interleukins in pathology
- autoimmune disease
- inhibitor of interleukins
- network of interleukins