Special Issue "Recent Advances in Intermediate Filaments"
Deadline for manuscript submissions: 31 May 2021.
Interests: lamin A/C; T cell; dendritic cell; inflammatory bowel disease; melanoma; pathogen infections; immunology
Intermediate filaments (IFs) are part of the cellular cytoskeleton and nucleoskeleton. They participate in the connection between the cell membrane and the nuclear interior with actin filaments, microtubules, and the linker of nucleoskeleton and cytoskeleton (LINC) complex. IFs are responsible for the critical structural integrity of cells and tissues and regulate several important cellular processes including cell migration and adhesion, apoptosis, proliferation, differentiation, autophagy, signaling, gene expression, vesicle trafficking, mitochondrial function, and cell fate determination. Although IFs are expressed in most cells, their expression is dynamic and subject to fine regulation involving post-translational modifications and intracellular proteolysis. Mutation in IF genes results in a wide range of human diseases; these filaments play important roles in the context of cancer, inflammation and other immune diseases, muscular syndromes, progeria, lipodystrophies, and digestive diseases.In this Special Issue, we invite investigators to submit original research or review articles on the many facets of intermediate filament and on recent insights in this field.Topics include but are not limited to the following:
- IF and mechanobiology
- IF modifications and regulation
- IF in nuclear function
- IF in signaling
- IF in digestive biology and diseases.
- IF in immunology and inflammation
- IF in cancer
- IF in laminopathies
- IF in muscular diseases
Dr. Jose Maria Gonzalez-Granado
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- intermediate filaments
- vesicle trafficking
- mitochondrial function
- digestive diseases
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Unidirectional regulation of vimentin intermediate filaments to caveolin-1
Abstract: Both the mechanosensitive vimentin cytoskeleton and endocytic caveolae contribute to active processes such as cell migration, morphogenesis and stress response. However, the crosstalk between these two systems has remained elusive. Here, we find that there is mutual exclusive subcellular expression between vimentin and cavolin-1, and vimentin filaments interact and arrest the cytoplasmic motility of caveolin-1. Importantly, vimentin depletion induces phosphorylation of caviloin-1 on Tyr14, and consequently, restores the compromised cell migration rete and directionality caused by caveolin-1 deprivation. Moreover, vimentin knockout further recovers the reduced intracellular motility of caveolin-1 upon hypo-osmotic shock. In contrary, caveolin-1 depletion has no effect on the expression, phosphorylation on Ser39, Ser 56 and Ser83, distribution, solubility, and cellular dynamics of vimentin. Taken together, our data reveals a one-way regulation of vimentin to caveolin-1, at least on the cellular level.
Title: Keratins are upregulated during hypoxia and complex with and modulate Hif1α signaling in colonic epithelia.
Title: Keratin 7 as a constituent of the keratin network in mouse pancreatic islets.